Massive Iatrogenic Outbreak of Human Immunodeficiency Virus Type 1 in Rural Cambodia, 2014-2015
| العنوان: | Massive Iatrogenic Outbreak of Human Immunodeficiency Virus Type 1 in Rural Cambodia, 2014-2015 |
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| المؤلفون: | Chunfu Yang, Sophearot Prak, Laurent Ferradini, Chandara Mom, Gérard Lesage, Catherine Gaudy-Graffin, Jean-Christophe Plantier, Sovatha Mam, Artur Ramos, Chhivun Mean, Marie Leoz, William Killam, Didier Fontenille, Francis Barin, Benjamin Roche, Sreymom Ken, Du-Ping Zheng, Allison Black, Alexandra Kerleguer, Vonthanak Saphonn, Janin Nouhin, François Rouet, Masami Fujita, Trevor Bedford, Charlotte Gautier, Kerya Phon |
| المساهمون: | Institut Pasteur du Cambodge, Réseau International des Instituts Pasteur (RIIP), Centers for Disease Control and Prevention [Atlanta] (CDC), Centers for Disease Control and Prevention, Institut de Recherche pour le Développement (IRD), Centre National de la Recherche Scientifique (CNRS), Fred Hutchinson Cancer Research Center [Seattle] (FHCRC), Groupe de Recherche sur l'Adaptation Microbienne (GRAM 2.0), Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Université de Caen Normandie (UNICAEN), Normandie Université (NU), Laboratoire de virologie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Département de microbiologie : Bactério, Virologie, Parasito, Hygiène, Morphogénèse et antigénicité du VIH et du virus des Hépatites (MAVIVH - U1259 Inserm - CHRU Tours ), Centre Hospitalier Régional Universitaire de Tours (CHRU Tours)-Université de Tours (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM), World Health Organization [Phnom Penh] (WHO), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Centers for Disease Control and Prevention [Phnom Penh], Embassy of the United States of America, University of Health Sciences [Phnom-Penh, Cambodia] (UHS), This work was supported by grants from the 5% Initiative Expertise France, the Institut Pasteur International Network, and the French National Agency for Research on AIDS and Viral Hepatitis. This research has been also partially been supported by the President’s Emergency Plan for AIDS Relief through the CDC (cooperative agreement number 3U2GGH000989)., Université de Tours-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS) |
| المصدر: | Clinical Infectious Diseases Clinical Infectious Diseases, Oxford University Press (OUP), 2018, 66 (11), pp.1733-1741. ⟨10.1093/cid/cix1071⟩ |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Rural Population, Iatrogenic Disease, HIV Infections, medicine.disease_cause, Disease Outbreaks, MESH: HIV-1, chemistry.chemical_compound, 0302 clinical medicine, MESH: Aged, 80 and over, iatrogenic outbreak, MESH: Rural Population, MESH: Child, HBV, 030212 general & internal medicine, MESH: Phylogeny, Child, [SDV.MP.MYC]Life Sciences [q-bio]/Microbiology and Parasitology/Mycology, Phylogeny, MESH: Aged, Aged, 80 and over, MESH: Middle Aged, Transmission (medicine), virus diseases, Hepatitis C, MESH: HIV Infections, Middle Aged, MESH: Case-Control Studies, MESH: Iatrogenic Disease, MESH: Cambodia/epidemiology, 3. Good health, Infectious Diseases, Child, Preschool, [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology, HCV, Female, Cambodia, Microbiology (medical), Adult, Adolescent, Hepatitis C virus, Disease cluster, [SDV.MP.PRO]Life Sciences [q-bio]/Microbiology and Parasitology/Protistology, Article, Injections, 03 medical and health sciences, Young Adult, medicine, MESH: Injections, Humans, Avidity, NS5B, Aged, Hepatitis B virus, MESH: Adolescent, MESH: Humans, business.industry, MESH: Child, Preschool, Outbreak, HIV, MESH: Adult, medicine.disease, Virology, [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology, MESH: Male, 030104 developmental biology, chemistry, Case-Control Studies, HIV-1, business, MESH: Female |
| الوصف: | Background In 2014–2015, 242 individuals aged 2–89 years were newly diagnosed with human immunodeficiency virus type 1 (HIV-1) in Roka, a rural commune in Cambodia. A case-control study attributed the outbreak to unsafe injections. We aimed to reconstruct the likely transmission history of the outbreak. Methods We assessed in 209 (86.4%) HIV-infected cases the presence of hepatitis C virus (HCV) and hepatitis B virus (HBV). We identified recent infections using antibody (Ab) avidity testing for HIV and HCV. We performed amplification, sequencing, and evolutionary phylogenetic analyses of viral strains. Geographical coordinates and parenteral exposure through medical services provided by an unlicensed healthcare practitioner were obtained from 193 cases and 1499 controls during interviews. Results Cases were coinfected with HCV (78.5%) and HBV (12.9%). We identified 79 (37.8%) recent ( Conclusions Unsafe injections in Cambodia most likely led to an explosive iatrogenic spreading of HIV, associated with a long-standing and more genetically diverse HCV propagation. |
| تدمد: | 1537-6591 1058-4838 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e08bb5addafa1659b64df167b0b583fb https://pubmed.ncbi.nlm.nih.gov/29211835 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e08bb5addafa1659b64df167b0b583fb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15376591 10584838 |
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