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Microbial Modulation of the Development and Physiology of the Enteric Nervous System

التفاصيل البيبلوغرافية
العنوان: Microbial Modulation of the Development and Physiology of the Enteric Nervous System
المؤلفون: François Leulier, Filipe De Vadder, Amélie Joly
المساهمون: Institut de Génomique Fonctionnelle de Lyon (IGFL), École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), ANR-18-CE15-0011,SymEnvLop,Symbiose bénéfique hôte-microbiote durant une sous nutrition chronique: Enveloppe bactérienne et promotion de la croissance linéaire(2018)
المصدر: Trends in Microbiology
Trends in Microbiology, Elsevier, 2021, 29 (8), pp.686-699. ⟨10.1016/j.tim.2020.11.007⟩
Trends in Microbiology, 2021, 29 (8), pp.686-699. ⟨10.1016/j.tim.2020.11.007⟩
بيانات النشر: Elsevier BV, 2021.
سنة النشر: 2021
مصطلحات موضوعية: Microbiology (medical), Fluid homeostasis, [SDV]Life Sciences [q-bio], Intestinal physiology, Motility, Physiology, Enteroendocrine cell, Gut flora, digestive system, Microbiology, 03 medical and health sciences, enteric nervous system, Immune system, Virology, microbiota, Homeostasis, Humans, 030304 developmental biology, Neurons, 0303 health sciences, Gastrointestinal tract, enteroendocrine cells, biology, 030306 microbiology, intestinal physiology, Gene Expression Regulation, Bacterial, biology.organism_classification, Gastrointestinal Microbiome, Intestines, Infectious Diseases, Enteric nervous system, intestinal immune system
الوصف: International audience; The gastrointestinal tract harbors an intrinsic neuronal network, the enteric nervous system (ENS). The ENS controls motility, fluid homeostasis and blood flow, but also interacts with other components of the intestine such as epithelial and immune cells. Recent studies indicate that gut microbiota diversification occurring concomitantly to postnatal ENS maturation could be critical for ENS development and function. Here we discuss the possibility that this functional relationship starts in utero, whereby the maternal microbiota would prime the developing ENS and shape its physiology. We review the ENS/microbiota interactions and their modulation in physiological and pathophysiological contexts. While the microbial modulation of ENS physiology is now well established, further studies are required to understand the contribution of the gut microbiota to the ENS development and pathologies and to reveal the precise mechanisms underlying microbiota-to-ENS communications.
تدمد: 0966-842X
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e09e87375d432e0874ada97d5ca36c40
https://doi.org/10.1016/j.tim.2020.11.007
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....e09e87375d432e0874ada97d5ca36c40
قاعدة البيانات: OpenAIRE
الوصف
تدمد:0966842X