Outcome measures for assessing the effectiveness of non-pharmacological interventions in frequent episodic or chronic migraine: A Delphi study
| العنوان: | Outcome measures for assessing the effectiveness of non-pharmacological interventions in frequent episodic or chronic migraine: A Delphi study |
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| المؤلفون: | Bjarne K Madsen, René F. Castien, Bettina Wollesen, Gwen Jull, César Fernández-de-las-Peñas, Benjamin Schaefer, Mirja Gustafsson, Harry von Piekartz, Kerstin Luedtke, Claudia Steen, Elizabeth K. Seng, Peter J. Tuchin, Deborah Falla, Peter Kropp, Stephanie Bedei, Toby Hall, Aleksander Chaibi, Annika Basener |
| المساهمون: | AMS - Rehabilitation & Development, Neuromechanics, APH - Health Behaviors & Chronic Diseases, APH - Aging & Later Life |
| المصدر: | BMJ Open, 10(2):029855. BMJ Publishing Group BMJ Open, Vol 10, Iss 2 (2020) Luedtke, K, Basener, A, Bedei, S, Castien, R, Chaibi, A, Falla, D, Fernández-De-Las-Peñas, C, Gustafsson, M, Hall, T, Jull, G, Kropp, P, Madsen, B K, Schaefer, B, Seng, E, Steen, C, Tuchin, P, Von Piekartz, H & Wollesen, B 2020, ' Outcome measures for assessing the effectiveness of non-pharmacological interventions in frequent episodic or chronic migraine : A Delphi study ', BMJ Open, vol. 10, no. 2, 029855 . https://doi.org/10.1136/bmjopen-2019-029855 Luedtke, K, Basener, A, Bedei, S, Castien, R, Chaibi, A, Falla, D, Fernández-De-Las-Peñas, C, Gustafsson, M, Hall, T, Jull, G, Kropp, P, Madsen, B K, Schaefer, B, Seng, E, Steen, C, Tuchin, P, Von Piekartz, H & Wollesen, B 2020, ' Outcome measures for assessing the effectiveness of non-pharmacological interventions in frequent episodic or chronic migraine: A Delphi study ', BMJ Open, vol. 10, no. 2, 029855 . https://doi.org/10.1136/bmjopen-2019-029855 BMJ Open |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Internationality, Delphi Technique, Migraine Disorders, Psychological intervention, Delphi method, Relaxation Therapy, Likert scale, Chronic Migraine, Quality of life (healthcare), Humans, Medicine, migraine, Exercise, Original Research, evaluation, research, Cognitive Behavioral Therapy, Manipulation, Chiropractic, business.industry, Acupuncture, General Medicine, SDG 10 - Reduced Inequalities, medicine.disease, Exercise Therapy, Clinical trial, Treatment Outcome, Neurology, Migraine, consensus, Chronic Disease, Physical therapy, Headaches, medicine.symptom, business, headache |
| الوصف: | ObjectivesThe aim of this Delphi survey was to establish an international consensus on the most useful outcome measures for research on the effectiveness of non-pharmacological interventions for migraine. This is important, since guidelines for pharmacological trials recommend measuring the frequency of headaches with 50% reduction considered a clinically meaningful effect. It is unclear whether the same recommendations apply to complementary (or adjunct) non-pharmacological approaches, whether the same cut-off levels need to be considered for effectiveness when used as an adjunct or stand-alone intervention, and what is meaningful to patients.SettingUniversity-initiated international survey.ParticipantsThe expert panel was chosen based on publications on non-pharmacological interventions in migraine populations and from personal contacts. 35 eligible researchers were contacted, 12 agreed to participate and 10 completed all 3 rounds of the survey. To further explore how migraine patients viewed potential outcome measures, four migraine patients were interviewed and presented with the same measurement tools as the researchers.ProceduresThe initial Delphi round was based on a systematic search of the literature for outcome measures used in non-pharmacological interventions for headache. Suggested outcome measures were rated by each expert, blinded towards the other members of the panel, for its usefulness on a 5-point Likert scale ranging from definitely not useful to extremely useful. Results were combined using median values and IQRs. Tools rated overall as definitely or probably not useful were excluded from subsequent rounds. Experts further suggested additional outcome measures that were presented to the panel in subsequent rounds. Additionally, experts were asked to rank the most useful tools and provide information on feasible cut-off levels for effectiveness for the three highest ranked tools.ResultsResults suggest the use of the Migraine Disability Assessment (MIDAS), Headache Impact Test (HIT-6) and headache frequency as primary outcome measures. Patient experts suggested the inclusion of a measure of quality of life and evaluation of associated symptoms and fear of attacks.ConclusionsRecommendations are for the use of the MIDAS, the HIT-6 and headache frequency, in combination with an outcome measure for quality of life. Associated symptoms and fear of attacks should also be considered as secondary outcomes, if relevant for the individual target population. The cut-off level for effectiveness should be lower for non-pharmacological interventions, especially when used as an adjunct to medication.Trial registration numberGerman Register of Clinical Trials (DRKS00011777) |
| اللغة: | English |
| تدمد: | 2044-6055 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e109abc99c12218c21d9b314f6b047a8 https://doi.org/10.1136/bmjopen-2019-029855 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e109abc99c12218c21d9b314f6b047a8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20446055 |
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