Occupational formaldehyde exposure linked to increased systemic health impairments and counteracting beneficial effects of selected antioxidants
| العنوان: | Occupational formaldehyde exposure linked to increased systemic health impairments and counteracting beneficial effects of selected antioxidants |
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| المؤلفون: | Zenebe Negeri, Solomon Tesfaye, Niguse Hamba, Asfaw Gerbi |
| المصدر: | Alexandria Journal of Medicine; Vol. 57 No. 1 (2021); 157-167 |
| بيانات النشر: | Faculty of Medicine, Alexandria University, 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | formaldehyde, occupational exposure, detrimental health effects, antioxidants, oxidative tissue damage, business.industry, fungi, Formaldehyde, food and beverages, 030209 endocrinology & metabolism, General Medicine, Systemic health, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Immune system, chemistry, Immunology, Medicine, 030212 general & internal medicine, Occupational exposure, business, Beneficial effects, FORMALDEHYDE EXPOSURE |
| الوصف: | Background: Formaldehyde (FA) is a sensitizing agent that can produce an effective immune system response upon initial exposure. FA that can be used in many industries, medical and anatomical facilities, mainly cadaver-based gross anatomy laboratories, represent a risk to occupational health of professionals and students. The majority of FA exposures occur through inhalation, dermal, and eye contact. FA-induced effects are attributed to site-specific and dosedependent health impairments in many organs and organ systems. Much progress has been reported on FA-induced health impairments in respiratory tract, but a comprehensive study in different organ systems and the reverse effects of some novel antioxidants is still lacking. This review explores the cytotoxic effects of FA and its role as key signaling molecule, site specific and or dose dependent effects of FA in nasal cavity, carcinogenic effects of FA exposure in nasopharynx, effects of FA in lung macrophage functions and development of pulmonary fibrosis, dose dependent reproductive and genetic effects of FA, neurotoxic effects of FA and potential risk of FA in some beauty salons and cosmetic products. In addition, this study shows the counteracting beneficial role of melatonin, Nigella sativa, rose oils, caffeic acid phenethyl ester (CAPE), vitamin E, and proanthocyanidins (PAs) against FA induced tissue damage.Methods: A comprehensive literature search highlighting the health impairments of FA and counteracting beneficial effects of promising antioxidants was conducted using PubMed, Google Scholar, and Medline Cochrane, to assemble relevant publications from open access international journals published only in English.Results: The search generated 411 articles of which 70 full research articles fulfilled the inclusion criteria and included in the review. The results of this study confirmed relentless toxic effects of FA exposure on various organs of human and other animals. Multiple findings also stated the efficacy of promising antioxidants against FA-induced tissue damage in animal models.Conclusion: Occupational exposure to FA is most likely due to inattention towards its side effects and lack of appropriate air filtering equipment or unmonitored concentration of FA in the working air. Therefore, re-evaluating the concentration of FA, proper ventilation, and assessment of working practices is highly recommended. Proper monitoring is also needed to improve compliance and protection of FA-based reproductive complications in females. Despite complete prevention is not viable, exposed personnel must be aware of FA-induced health effects and require assessing risks and acquiring practical measures in their working environment. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1110-0834 2090-2948 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e11a1d91e1c85b6bdec0e0eaf6301e7e https://www.ajol.info/index.php/bafm/article/view/232115 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e11a1d91e1c85b6bdec0e0eaf6301e7e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 11100834 20902948 |
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