Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection
| العنوان: | Long-lived antigen-induced IgM plasma cells demonstrate somatic mutations and contribute to long-term protection |
|---|---|
| المؤلفون: | Miri Michaeli, Joshy Jacob, Lakshmipriyadarshini Satyabhama, Ignacio Sanz, Caitlin Bohannon, Ang Cui, Ramit Mehr, Ioanna Skountzou, Steven H. Kleinstein, Robert S. Mittler, Frances Eun-Hyung Lee, Christopher M. Tipton, Ryan Powers |
| المصدر: | Nature Communications Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016) |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Science, Amino Acid Motifs, Plasma Cells, General Physics and Astronomy, Somatic hypermutation, General Biochemistry, Genetics and Molecular Biology, Affinity maturation, 03 medical and health sciences, Antigen, Orthomyxoviridae Infections, Neutralization Tests, Cytidine Deaminase, Animals, Antigens, Multidisciplinary, biology, Immunity, Germinal center, General Chemistry, Germinal Center, Orthomyxoviridae, Adoptive Transfer, Complementarity Determining Regions, Corrigenda, 3. Good health, B-1 cell, Mice, Inbred C57BL, 030104 developmental biology, Immunoglobulin M, Immunology, Humoral immunity, Mutation, biology.protein, Somatic Hypermutation, Immunoglobulin, Antibody, Immunoglobulin Heavy Chains, Spleen |
| الوصف: | Long-lived plasma cells are critical to humoral immunity as a lifelong source of protective antibodies. Antigen-activated B cells—with T-cell help—undergo affinity maturation within germinal centres and persist as long-lived IgG plasma cells in the bone marrow. Here we show that antigen-specific, induced IgM plasma cells also persist for a lifetime. Unlike long-lived IgG plasma cells, which develop in germinal centres and then home to the bone marrow, IgM plasma cells are primarily retained within the spleen and can develop even in the absence of germinal centres. Interestingly, their expressed IgV loci exhibit somatic mutations introduced by the activation-induced cytidine deaminase (AID). However, these IgM plasma cells are probably not antigen-selected, as replacement mutations are spread through the variable segment and not enriched within the CDRs. Finally, antibodies from long-lived IgM plasma cells provide protective host immunity against a lethal virus challenge. |
| تدمد: | 2041-1723 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e18e1582233725f8efb5879e0fef0219 https://pubmed.ncbi.nlm.nih.gov/27527920 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e18e1582233725f8efb5879e0fef0219 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20411723 |
|---|