The soluble mannose receptor (sMR/sCD206) in critically ill patients with invasive fungal infections, bacterial infections or non-infectious inflammation: a secondary analysis of the EPaNIC RCT
| العنوان: | The soluble mannose receptor (sMR/sCD206) in critically ill patients with invasive fungal infections, bacterial infections or non-infectious inflammation: a secondary analysis of the EPaNIC RCT |
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| المؤلفون: | Holger Jon Møller, Greet Van den Berghe, Inge Derese, Pieter Wouters, Catherine Ingels, Greet Hermans, Michael P Casaer, Greet De Vlieger, Ilse Vanhorebeek, Philippe Meersseman, Yves Debaveye |
| المصدر: | Critical Care, Vol 23, Iss 1, Pp 1-9 (2019) De Vlieger, G, Vanhorebeek, I, Wouters, P J, Derese, I, Casaer, M P, Debaveye, Y, Hermans, G, Meersseman, P, Møller, H J, Van Den Berghe, G & Ingels, C 2019, ' The soluble mannose receptor (sMR/sCD206) in critically ill patients with invasive fungal infections, bacterial infections or non-infectious inflammation : A secondary analysis of the EPaNIC RCT ', Critical Care, vol. 23, no. 1, 270 . https://doi.org/10.1186/s13054-019-2549-8 Critical Care |
| بيانات النشر: | BMC, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Time Factors, Critical Illness, Receptors, Cell Surface, sCD206, sMR, Critical Care and Intensive Care Medicine, law.invention, Sepsis, 03 medical and health sciences, 0302 clinical medicine, Invasive fungal infection, Randomized controlled trial, law, Internal medicine, Intensive care, Severity of illness, Humans, Medicine, Lectins, C-Type, 030212 general & internal medicine, Macrophage activation, Soluble CD206, Aged, 030304 developmental biology, Inflammation, Analysis of Variance, 0303 health sciences, business.industry, Research, lcsh:Medical emergencies. Critical care. Intensive care. First aid, Soluble mannose receptor, Bacterial Infections, lcsh:RC86-88.9, Middle Aged, medicine.disease, Intensive care unit, 3. Good health, Mannose-Binding Lectins, Parenteral nutrition, ROC Curve, Biomarker (medicine), Female, Analysis of variance, business, Biomarkers, Invasive Fungal Infections, Mannose Receptor |
| الوصف: | Background Invasive fungal infections (IFI) are difficult to diagnose, especially in critically ill patients. As the mannose receptor (MR) is shed from macrophage cell surfaces after exposure to fungi, we investigate whether its soluble serum form (sMR) can serve as a biomarker of IFI. Methods This is a secondary analysis of the multicentre randomised controlled trial (EPaNIC, n = 4640) that investigated the impact of initiating supplemental parenteral nutrition (PN) early during critical illness (Early-PN) as compared to withholding it in the first week of intensive care (Late-PN). Serum sMR concentrations were measured in three matched patient groups (proven/probable IFI, n = 82; bacterial infection, n = 80; non-infectious inflammation, n = 77) on the day of antimicrobial initiation or matched intensive care unit day and the five preceding days, as well as in matched healthy controls (n = 59). Independent determinants of sMR concentration were identified via multivariable linear regression. Serum sMR time profiles were analysed with repeated-measures ANOVA. Predictive properties were assessed via area under the receiver operating curve (aROC). Results Serum sMR was higher in IFI patients than in all other groups (all p |
| وصف الملف: | Electronic |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1adc84715c26c6f41c87a9669bb6726 https://lirias.kuleuven.be/handle/123456789/639861 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e1adc84715c26c6f41c87a9669bb6726 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |