Ribavirin and Interferon-α2b as Primary and Preventive Treatment for Middle East Respiratory Syndrome Coronavirus: A Preliminary Report of Two Cases
| العنوان: | Ribavirin and Interferon-α2b as Primary and Preventive Treatment for Middle East Respiratory Syndrome Coronavirus: A Preliminary Report of Two Cases |
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| المؤلفون: | Fahad Al Rabiah, Eid Al Mutairy, Abdullah Al Mobeireek, Mohammed Khalid, Basha Khan, Taimur Butt |
| المصدر: | Antiviral Therapy. 20:87-91 |
| بيانات النشر: | SAGE Publications, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, Interferon α2b, medicine.medical_specialty, Combination therapy, Middle East respiratory syndrome coronavirus, viruses, Interferon alpha-2, medicine.disease_cause, Antiviral Agents, Polyethylene Glycols, chemistry.chemical_compound, Preliminary report, Internal medicine, Ribavirin, Case fatality rate, medicine, Humans, Pharmacology (medical), Respiratory system, Coronavirus, Pharmacology, business.industry, Interferon-alpha, virus diseases, Middle Aged, Viral Load, Virology, Recombinant Proteins, Radiography, Infectious Diseases, chemistry, Middle East Respiratory Syndrome Coronavirus, Female, Coronavirus Infections, business |
| الوصف: | Middle East respiratory syndrome coronavirus (MERS-CoV) is a newly recognized transmissible viral infection with high virulence and case fatality rates for which there is no currently defined primary treatment or prophylaxis. Saudi Arabia has the largest reported number of cases so far. Like severe acute respiratory syndrome (SARS), MERS is caused by a coronavirus. Combination therapy with interferon-α2b and ribavirin has been used successfully as primary treatment and prophylaxis in SARS. Because of similarities between the two coronaviruses, treatment with ribavarin and interferon-α2b has been suggested as a potential therapy for MERS-CoV. Studies in animal models of MERS-CoV have shown the combination of ribavirin and interferon-α2b to be effective both as primary treatment and prophylaxis. In this report, we describe for the first time use of this combination as a primary treatment for a patient with MERS-CoV infection and as prophylaxis for his spouse and discuss its possible role. |
| تدمد: | 2040-2058 1359-6535 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1fb912f67d92de33f9e4d70ba0ee52b https://doi.org/10.3851/imp2792 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e1fb912f67d92de33f9e4d70ba0ee52b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20402058 13596535 |
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