Absence of a synergic nigral proapoptotic effect triggered by REM sleep deprivation in the rotenone model of Parkinson´s disease
| العنوان: | Absence of a synergic nigral proapoptotic effect triggered by REM sleep deprivation in the rotenone model of Parkinson´s disease |
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| المؤلفون: | Lais S. Rodrigues, Luana C Kmita, Adriano D.S. Targa, Marcelo M.S. Lima, Patrícia Dos-Santos, Ana Carolina D. Noseda, Juliane Fagotti, Edvaldo S. Trindade, Jessica L. Ilkiw |
| المصدر: | Sleep Science, Vol 12, Iss 3, Pp 196-202 (2019) Sleep Science |
| بيانات النشر: | Brazilian Association of Sleep and Latin American Federation of Sleep Societies, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Parkinson's disease, parkinson’s disease, lcsh:BF1-990, Neuroscience (miscellaneous), Excitotoxicity, Medicine (miscellaneous), Nigrostriatal pathway, lcsh:Consciousness. Cognition, intranigral rotenone, medicine.disease_cause, Neuroprotection, 03 medical and health sciences, Behavioral Neuroscience, 0302 clinical medicine, Dopamine, medicine, 030219 obstetrics & reproductive medicine, business.industry, Dopaminergic, Glutamate receptor, medicine.disease, lcsh:BF309-499, riluzole, Riluzole, medicine.anatomical_structure, lcsh:Psychology, Original Article, neuroprotection, business, Neuroscience, excitotoxicity, 030217 neurology & neurosurgery, rem sleep deprivation, medicine.drug |
| الوصف: | Excitotoxicity has been related to play a crucial role in Parkinson’s disease (PD) pathogenesis. Pedunculopontine tegmental nucleus (PPT) represents one of the major sources of glutamatergic afferences to nigrostriatal pathway and putative reciprocal connectivity between these structures may exert a potential influence on rapid eye movement (REM) sleep control. Also, PPT could be overactive in PD, it seems that dopaminergic neurons are under abnormally high levels of glutamate and consequently might be more vulnerable to neurodegeneration. We decided to investigate the neuroprotective effect of riluzole administration, a N-methyl-D-aspartate (NMDA) receptor antagonist, in rats submitted simultaneously to nigrostrial rotenone and 24h of REM sleep deprivation (REMSD). Our findings showed that blocking NMDA glutamatergic receptors in the SNpc, after REMSD challenge, protected the dopaminergic neurons from rotenone lesion. Concerning rotenone-induced hypolocomotion, riluzole reversed this impairment in the control groups. Also, REMSD prevented the occurrence of rotenone-induced motor impairment as a result of dopaminergic supersensitivity. In addition, higher Fluoro Jade C (FJC) staining within the SNpc was associated with decreased cognitive performance observed in rotenone groups. Such effect was counteracted by riluzole suggesting the occurrence of an antiapoptotic effect. Moreover, riluzole did not rescue cognitive impairment impinged by rotenone, REMSD or their combination. These data indicated that reductions of excitotoxicity, by riluzole, partially protected dopamine neurons from neuronal death and appeared to be effective in relieve specific rotenone-induce motor disabilities. |
| اللغة: | English |
| تدمد: | 1984-0063 1984-0659 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27a45b50da55419e4436d293591f61f http://sleepscience.org.br/export-pdf/650/ssci-12-03-0196.pdf |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e27a45b50da55419e4436d293591f61f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19840063 19840659 |
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