THE ROLE OF GROWTH DIFFERENTIATION FACTOR 11 (GDF11) IN REGULATION OF LIPID METAbOLISM AND CARDIOHEMODYNAMIC FUNCTIONS IN ESSENTIAL HYPERTENSION PATIENTS IN MODERATE EFFORT ExERCISES
| العنوان: | THE ROLE OF GROWTH DIFFERENTIATION FACTOR 11 (GDF11) IN REGULATION OF LIPID METAbOLISM AND CARDIOHEMODYNAMIC FUNCTIONS IN ESSENTIAL HYPERTENSION PATIENTS IN MODERATE EFFORT ExERCISES |
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| المؤلفون: | I. V. Fine, S. O. Davydov, E. S. Guseva, E. Magen, Yu. N. Smolyakov, A. V. Stepanov, B. I. Kuznik |
| المصدر: | Российский кардиологический журнал, Vol 0, Iss 4, Pp 93-98 (2018) |
| بيانات النشر: | Silicea - Poligraf, LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | 0301 basic medicine, business.industry, essential hypertension, gdf11, blood pressure, moderate exertion, Lipid metabolism, 030204 cardiovascular system & hematology, hemodynamics, Essential hypertension, medicine.disease, Bioinformatics, 03 medical and health sciences, 030104 developmental biology, 0302 clinical medicine, kinesitherapy, cardiodynamics, RC666-701, GDF11, medicine, Diseases of the circulatory (Cardiovascular) system, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Aim. To reveal the role of a “youth protein” GDF11 in regulation of lipid metabolism and cardiovascular system work in essential hypertension (EH) in women taking antihypertension medications and regularly involved in moderate physical exercises (kinesitherapy).Material and methods. In all participants, the level of GDF11 was measured by immune enzyme assay, and levels of lipids; registration was done of blood pressure, echocardiography and circulation condition with a novel sensor of dynamic light scattering (mDLS).Results. In women with AH taking antihypertension medications, the level of GDF11 was lower more than 3 times. In EH patients the deviations found, in a shear flow velocity with significant increase of rapid velocity processes. Correlations found for GDF11 level with the age, blood pressure, condition of the heart work, hemodynamical and oscillatory indexes. In the EH group patients regularly doing exercises (kinesitherapy), the level of GDF11, blood pressure, lipid profile and all parameters of heart work and hemodynamics are close to normal.Conclusion. The “youth protein” CDF11 is a factor of prevention of AH. Kinesitherapy in EH patients normalizes GDF11, lipid profile, and significantly increases the work of cardiovascular system. |
| تدمد: | 2618-7620 1560-4071 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2b19828cfc17250e76ebdeb5d30c767 https://doi.org/10.15829/1560-4071-2018-4-93-98 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e2b19828cfc17250e76ebdeb5d30c767 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 26187620 15604071 |
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