Peripheral Leakage on Ultra-Widefield Fluorescein Angiography in Patients With Inherited Retinal Degeneration
| العنوان: | Peripheral Leakage on Ultra-Widefield Fluorescein Angiography in Patients With Inherited Retinal Degeneration |
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| المؤلفون: | Rachel M. Huckfeldt, Elli A. Park, Lucia Sobrin, Jason Comander |
| المصدر: | J Vitreoretin Dis |
| بيانات النشر: | SAGE Publications, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | 0301 basic medicine, Retinal degeneration, medicine.medical_specialty, medicine.diagnostic_test, business.industry, 030105 genetics & heredity, Vascular leakage, medicine.disease, Fluorescein angiography, Peripheral, 03 medical and health sciences, 0302 clinical medicine, Ophthalmology, 030221 ophthalmology & optometry, Medicine, Case Series, In patient, business, Leakage (electronics) |
| الوصف: | Purpose: This report illustrates that peripheral vascular leakage on ultra-widefield fluorescein angiography (FA) can occur in patients with inherited retinal degeneration (IRD) without evidence of a separate cause of leakage. Methods: We searched the electronic medical records of the Massachusetts Eye and Ear Infirmary from 2010 to 2019 for patients with an IRD diagnosis and examination with an ultra-widefield FA. Images from FAs were evaluated in masked fashion by 2 retina specialists. Documentation of an evaluation for alternative causes of vascular leakage was recorded, as well as results from electroretinography, Goldmann perimetry, and genetic testing. Results: A total of 305 patients with an IRD diagnosis and FA procedure code were identified. Of these, 26 patients had both a clinical diagnosis of IRD and ultra-widefield FA on detailed medical-record review. Three patients had FA to evaluate a Coats-like response and were excluded. Of the remaining 23, 4 patients (17%) had significant peripheral leakage on FA. Of these, 1 had pericentral retinitis pigmentosa (for which the genetic cause of disease was undefined), 1 had Refsum disease with confirmed biallelic PHYH mutations, 1 had a CRB1-associated macular dystrophy, and 1 had CERKL-associated macular dystrophy. There was no evidence of ocular inflammation from history, examination, or laboratory testing to account for the FA findings. Of the 19 patients without significant leakage, 4 had minimal leakage and 15 had no peripheral leakage. Conclusions: Peripheral retinal vascular leakage can be seen on ultra-widefield FA in patients with IRD that is likely due to the IRD disease process itself rather than to an additional, distinct eye condition. |
| تدمد: | 2474-1272 2474-1264 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2bbf978e359568bf19022c2578f897b https://doi.org/10.1177/2474126420951988 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e2bbf978e359568bf19022c2578f897b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24741272 24741264 |
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