Pharmacologic Interventions for Fracture Risk Reduction in the Oldest Old: What Is the Evidence?
| العنوان: | Pharmacologic Interventions for Fracture Risk Reduction in the Oldest Old: What Is the Evidence? |
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| المؤلفون: | Robert J. Pignolo, Jad G Sfeir |
| المصدر: | JBMR Plus, Vol 5, Iss 10, Pp n/a-n/a (2021) JBMR Plus |
| بيانات النشر: | Wiley, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Gerontology, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, Population, Osteoporosis, Psychological intervention, Diseases of the musculoskeletal system, OSTEOPOROSIS, Special Issues, SARCOPENIA, AGING, Medicine, Orthopedics and Sports Medicine, education, Adverse effect, Reduction (orthopedic surgery), Polypharmacy, Orthopedic surgery, education.field_of_study, business.industry, Special Issue, ANTIRESORPTIVES, medicine.disease, FRACTURE PREVENTION, Clinical trial, RC925-935, Sarcopenia, business, RD701-811 |
| الوصف: | With an increasingly older population, the proportion of patients 85 years or older seeking interventions to protect their musculoskeletal health is growing. Osteoporosis in the geriatric population presents unique diagnostic and therapeutic challenges. Multimorbidity, frailty, falls, polypharmacy, and other neurobehavioral factors influence our approach to fracture prevention in this population. The vast majority of the evidence from clinical trials establish pharmacologic fracture efficacy in postmenopausal women. The evidence is scarce for the oldest old men and women, a population also at risk for adverse events and mortality. Most studies show continued efficacy of pharmacologic interventions in this age group, although they are largely limited by small sample sizes. We herein review the available evidence of pharmacologic interventions for fracture risk reduction in this population and explore the emerging senotherapeutic interventions in the pipeline. © 2021 The Authors. JBMR Plus published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research. |
| اللغة: | English |
| تدمد: | 2473-4039 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2cf7fde98cab2a394f4aea96713704d https://doaj.org/article/a43bce80f00844bcb5219ddda4ed6aa8 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e2cf7fde98cab2a394f4aea96713704d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 24734039 |
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