Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea ( Coprinus cinereus )
| العنوان: | Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea ( Coprinus cinereus ) |
|---|---|
| المؤلفون: | Patricia J. Pukkila, Claire Burns, Mark L. Farman, Gerard Manning, Björn Canbäck, Ashleigh Huggins, Heather J. Palmerini, Hoi Shan Kwan, Aaron J. Mackey, David C. Fargo, Jixin Deng, Chinnapa Kodira, Vardges Ter-Hovhannisyan, Allen C. Gathman, Chun Hang Au, Sreedhar Kilaru, Dag Ahrén, Jonathan M. Goldberg, Fred S. Dietrich, Donald O. Natvig, Patrick J. Hoegger, Mario Stanke, Miriam E. Zolan, Bruce W. Birren, Alexandre Lomsadze, Weixi Li, Bruce A. Roe, Hajime Muraguchi, Sarah K. Wilke, Doris M. Kupfer, Roderic Guigó, Cathy J. Rehmeyer, Ursula Kües, Francis Martin, Walt W. Lilly, Narmada Shenoy, Chi Keung Cheng, Anders Tunlid, Takashi Kamada, Lorna A. Casselton, Li-Jun Ma, Mark Borodovsky, James B. Hooker, Timothy Y. James, Rajesh Velagapudi, Qiandong Zeng, Jason E. Stajich, Marilee A. Ramesh |
| المصدر: | Proceedings of the National Academy of Sciences. 107:11889-11894 |
| بيانات النشر: | Proceedings of the National Academy of Sciences, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Retroelements, Molecular Sequence Data, Coprinus, Genome, Evolution, Molecular, Fungal Proteins, 03 medical and health sciences, Cytochrome P-450 Enzyme System, Meiosis, Gene Duplication, Commentaries, Gene family, Gene, Phylogeny, DNA Primers, 030304 developmental biology, Synteny, Recombination, Genetic, Genetics, 0303 health sciences, Multidisciplinary, Base Sequence, biology, 030306 microbiology, fungi, Fungal genetics, Chromosome Mapping, RNA, Fungal, biology.organism_classification, Coprinopsis cinerea, Multigene Family, Chromosomes, Fungal, Genome, Fungal, Protein Kinases |
| الوصف: | The mushroom Coprinopsis cinerea is a classic experimental model for multicellular development in fungi because it grows on defined media, completes its life cycle in 2 weeks, produces some 10 8 synchronized meiocytes, and can be manipulated at all stages in development by mutation and transformation. The 37-megabase genome of C. cinerea was sequenced and assembled into 13 chromosomes. Meiotic recombination rates vary greatly along the chromosomes, and retrotransposons are absent in large regions of the genome with low levels of meiotic recombination. Single-copy genes with identifiable orthologs in other basidiomycetes are predominant in low-recombination regions of the chromosome. In contrast, paralogous multicopy genes are found in the highly recombining regions, including a large family of protein kinases (FunK1) unique to multicellular fungi. Analyses of P450 and hydrophobin gene families confirmed that local gene duplications drive the expansions of paralogous copies and the expansions occur in independent lineages of Agaricomycotina fungi. Gene-expression patterns from microarrays were used to dissect the transcriptional program of dikaryon formation (mating). Several members of the FunK1 kinase family are differentially regulated during sexual morphogenesis, and coordinate regulation of adjacent duplications is rare. The genomes of C. cinerea and Laccaria bicolor , a symbiotic basidiomycete, share extensive regions of synteny. The largest syntenic blocks occur in regions with low meiotic recombination rates, no transposable elements, and tight gene spacing, where orthologous single-copy genes are overrepresented. The chromosome assembly of C. cinerea is an essential resource in understanding the evolution of multicellularity in the fungi. |
| تدمد: | 1091-6490 0027-8424 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2e19918e662b86fc2600b229ee2f379 https://doi.org/10.1073/pnas.1003391107 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e2e19918e662b86fc2600b229ee2f379 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 10916490 00278424 |
|---|