Diagnostic accuracy of repeat placental growth factor measurements in women with suspected preeclampsia: A case series study
| العنوان: | Diagnostic accuracy of repeat placental growth factor measurements in women with suspected preeclampsia: A case series study |
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| المؤلفون: | Jenny Myers, Lucy C Chappell, Kate E. Duhig, Andrew Sharp, Louise Webster, Carolyn Gill, Paul T. Seed, Andrew Shennan |
| المصدر: | Acta Obstetricia et Gynecologica Scandinavica Duhig, K E, Webster, L M, Sharp, A, Gill, C, Seed, P T, Shennan, A H, Myers, J E & Chappell, L C 2020, ' Diagnostic accuracy of repeat placental growth factor measurements in women with suspected preeclampsia : A case series study ', Acta Obstetricia et Gynecologica Scandinavica, vol. 99, no. 8, pp. 994-1002 . https://doi.org/10.1111/aogs.13818, https://doi.org/10.1111/aogs.13818 ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA |
| بيانات النشر: | John Wiley and Sons Inc., 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Placental growth factor, medicine.medical_specialty, placental growth factor, Disease, Risk Assessment, Sensitivity and Specificity, Preeclampsia, preeclampsia, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, Predictive Value of Tests, Pregnancy, Humans, Medicine, Sampling (medicine), 030212 general & internal medicine, Original Research Article, Placenta Growth Factor, 030219 obstetrics & reproductive medicine, Receiver operating characteristic, business.industry, Obstetrics, Pregnancy Outcome, Obstetrics and Gynecology, General Medicine, Diagnostic test, medicine.disease, Confidence interval, Gestation, Female, business, Biomarkers, Case series |
| الوصف: | INTRODUCTION: Preeclampsia affects about 3% of singleton pregnancies and is characterized by placental dysfunction. It is associated with significant maternal and perinatal morbidity and mortality. The diagnosis of preeclampsia remains a challenge, and the clinical course can develop for weeks before a diagnosis is confirmed. National guidelines have approved placental growth factor (PlGF) testing to rule out suspected preeclampsia, but the utility of repeated PlGF measurement is unknown. The aim of this case series analysis was to evaluate the test performance of repeated PlGF sampling in women presenting with suspected preeclampsia, and to describe relevant clinical outcomes.MATERIAL AND METHODS: Women who presented to maternity services with suspected preeclampsia between 20 +0 and 36 +6 weeks' gestation who underwent repeat PlGF sampling with a minimum test interval of 7 days were assessed. The outcomes were delivery for preeclampsia within 14 days of sampling, the proportion changing PlGF categories, and time to delivery. RESULTS: In total, 289 women with suspected preeclampsia undergoing repeat PlGF sampling were included. PlGF CONCLUSIONS: Repeat PlGF measurement demonstrates high negative predictive value for determining preeclampsia requiring delivery in 14 days. Repeat testing may be clinically useful to risk stratify women with ongoing symptoms of disease. Confirmation of the impact of these findings is required in further studies. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 1600-0412 0001-6349 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2f12cf244c133194562275efd681b1f http://europepmc.org/articles/PMC7496131 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e2f12cf244c133194562275efd681b1f |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 16000412 00016349 |
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