Effect Evaluation of Strychnos nux-vomica L. with Integrative Methods for Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma Patients: A Self-Controlled Clinical Trial
| العنوان: | Effect Evaluation of Strychnos nux-vomica L. with Integrative Methods for Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma Patients: A Self-Controlled Clinical Trial |
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| المؤلفون: | Jun Pei, Chu-Chu Chen, Zhi-Ping Hu, Jian-ping Shen, Li-Li Hong, Xue Yang, Tie-ying Dai, Hang-Ping Ge, Wen-Qi Lyu |
| المصدر: | Chinese Journal of Integrative Medicine. 27:131-136 |
| بيانات النشر: | Springer Science and Business Media LLC, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, 0211 other engineering and technologies, 02 engineering and technology, Traditional Chinese medicine, 030226 pharmacology & pharmacy, Gastroenterology, Bortezomib, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, 021105 building & construction, Strychnos nux-vomica, medicine, Humans, Pharmacology (medical), Adverse effect, Multiple myeloma, biology, business.industry, Neurotoxicity, Peripheral Nervous System Diseases, General Medicine, medicine.disease, biology.organism_classification, Clinical trial, Peripheral neuropathy, Complementary and alternative medicine, Seeds, Multiple Myeloma, business, medicine.drug |
| الوصف: | To explore the clinical effect and adverse reactions of Strychnos nux-vomica in bortezomib-induced peripheral neuropathy (BIPN) of patients with multiple myeloma (MM).A total of 19 MM patients with BIPN were enrolled and Nux Vomica Capsule (NVC, 0.4 g, thrice daily) were orally administrated for 30 days. Comparative analysis on parameters between pre- and post-therapy, including peripheral neuropathy (PN) grade, neurotoxicity score, Chinese medicine (CM) syndrome score, total neuropathy score (TNS), coagulation function, and serum nerve growth factor (NGF) levels were conducted. The adverse events were monitored.In BIPN of MM patients who received NVC, PN grade was lowered, neurotoxicity score was obviously decreased (P⩽0.01), and both CM syndrome score and TNS were remarkably decreased (P0.01). After the therapy, activated partial thromboplastin time was prolonged (P0.01) and fibrinogen was declined (P0.05), showing improvement in the hypercoagulable state of patients. No significant difference of NGF recovery degrees was detected between pre- and post-therapy (P0.05). No evident adverse reactions were observed during the course of treatment.Strychnos nux-vomica L. has significantly effect with a good safety in treatment of BIPN in MM patients. |
| تدمد: | 1993-0402 1672-0415 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36a72ae0c725ec040d2ea589584e75e https://doi.org/10.1007/s11655-020-3196-2 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e36a72ae0c725ec040d2ea589584e75e |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19930402 16720415 |
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