The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons
| العنوان: | The p75 Neurotrophin Receptor Facilitates TrkB Signaling and Function in Rat Hippocampal Neurons |
|---|---|
| المؤلفون: | Wilma J. Friedman, Laura Ester Montroull, Juan P. Zanin, Marta Volosin |
| المصدر: | Frontiers in Cellular Neuroscience Frontiers in Cellular Neuroscience, Vol 13 (2019) |
| بيانات النشر: | Frontiers Media SA, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | 0301 basic medicine, Receptor complex, Tropomyosin receptor kinase B, Tropomyosin receptor kinase A, lcsh:RC321-571, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Low-affinity nerve growth factor receptor, p75 neurotrophin receptor, Receptor, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, Original Research, Brain-derived neurotrophic factor, biology, Chemistry, Akt, TrkB, Cell biology, Erk, 030104 developmental biology, nervous system, brain derived neurotrophic factor, Trk receptor, biology.protein, sense organs, 030217 neurology & neurosurgery, Neuroscience, Neurotrophin |
| الوصف: | Neurotrophins activate Trk receptor signaling to support neuronal survival and many aspects of neuronal function. Early studies demonstrated that TrkA formed a complex with the p75 neurotrophin receptor (p75 NTR ), which increased the affinity and selectivity of NGF binding, however, whether interaction of p75 NTR with other Trk receptors performs a similar function to enhance ligand binding has not been demonstrated. We investigated the interaction of TrkB with full length p75 NTR in hippocampal neurons in response to BDNF and found that the association of these receptors occurs after ligand binding and requires phosphorylation of TrkB, indicating that formation of this receptor complex was not necessary for ligand binding. Moreover, the interaction of these receptors required internalization and localization to early endosomes. We found that association of TrkB with p75 NTR was necessary for optimal downstream signaling of the PI3K-Akt pathway, but not the Erk pathway, in hippocampal neurons. The absence of p75 NTR impaired the ability of BDNF to rescue hippocampal neurons in a trophic deprivation model, suggesting that p75 NTR facilitates the ability of TrkB to activate specific pathways to promote neuronal survival. |
| تدمد: | 1662-5102 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3897f2734edfb38e0aa34e576b1b507 https://doi.org/10.3389/fncel.2019.00485 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e3897f2734edfb38e0aa34e576b1b507 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16625102 |
|---|