Docetaxel Inhibits Urethral Stricture Formation, an Initial Study in Rabbit Model
| العنوان: | Docetaxel Inhibits Urethral Stricture Formation, an Initial Study in Rabbit Model |
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| المؤلفون: | Tie Chong, Hui-bo Zhang, Ziming Wang, Hecheng Li, Delai Fu |
| المصدر: | PLoS ONE PLoS ONE, Vol 9, Iss 11, p e112097 (2014) |
| بيانات النشر: | Public Library of Science, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Bacterial Diseases, Male, Urethral stricture, H&E stain, Pilot Projects, Docetaxel, chemistry.chemical_compound, Medicine and Health Sciences, Public and Occupational Health, Multidisciplinary, Animal Models, medicine.anatomical_structure, Infectious Diseases, Paclitaxel, Research Design, Urinary Tract Infections, Medicine, Taxoids, Collagen, Rabbits, medicine.drug, Research Article, medicine.medical_specialty, Clinical Research Design, Science, Urology, Lumen (anatomy), Surgical and Invasive Medical Procedures, Minimally Invasive Surgery, Research and Analysis Methods, Drug Administration Schedule, Model Organisms, medicine, Animals, Animal Models of Disease, Sirius Red, Urethral Stricture, business.industry, Biology and Life Sciences, medicine.disease, Urinary tract disorder, Surgery, Urodynamics, Disease Models, Animal, Urethra, chemistry, Animal Studies, Preventive Medicine, business, Endourology |
| الوصف: | IntroductionUrethral stricture, a frequent source of lower urinary tract disorders in men, is still a difficult problem for urologists. Based the anti-restenosis effect of paclitaxel on coronary artery, the role of docetaxel, a semi-synthetic analogue of paclitaxel, in limiting urethral stricture formation was studied.MethodsForty adult New Zealand male rabbits were involved in this study, which were randomly assigned into 3 groups, namely a high dose docetaxel (DH, 0.1 mg/d), a low dose docetaxel (DL, 0.01 mg/d) and a control (C) group, with 16, 16, 8 rabbits in each group, respectively. All animals underwent a 10 mm-long circumferential electrocoagulation of the bulbar urethra with a 13Fr pediatric resectoscope. Drugs were given by urethral irrigation daily and continuous for 28 days. Stricture formation was assessed by retrograde urethrography and videourethroscopy. Urethra pathology was evaluated by hematoxylin and eosin staining and Sirius red staining.ResultsAt the end of this study, 15, 14 and 7 rabbits remained for evaluation in DH, DL and C group, respectively. Urethral diameters in DH, DL and C group were (7.17±1.63) mm, (6.55±0.62) mm, (3.23±1.36) mm, with a normal urethral diameter of (9.08±1.29) mm. Lumen reduction in DH, DL and C group were (36.93±11.58)%, (48.03±7.89)% and (84.66±14.95)%, respectively. Statistically difference could be found between every two groups (pConclusionsDocetaxel could limit urethral stricture formation, which may be due to inhibition of fibrous tissue and collagen expression. Docetaxel may become a new choice in the prevention of urethral stricture formation. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3ba50dc1122383be1a8ca523f9ff0ef http://europepmc.org/articles/PMC4223003 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e3ba50dc1122383be1a8ca523f9ff0ef |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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