Incidence and risk factors for tenofovir-associated renal toxicity in HIV-infected patients
| العنوان: | Incidence and risk factors for tenofovir-associated renal toxicity in HIV-infected patients |
|---|---|
| المؤلفون: | Jimena Ramon Garcia, Rocío Vázquez Sánchez, Pedro Rodriguez Quesada, Laura López Esteban, Teresa Molina García, Javier Sánchez-Rubio Ferrández, G. Gaspar Alonso-Vega |
| المصدر: | International Journal of Clinical Pharmacy. 37:865-872 |
| بيانات النشر: | Springer Science and Business Media LLC, 2015. |
| سنة النشر: | 2015 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Anti-HIV Agents, Pharmaceutical Science, Renal function, HIV Infections, Pharmacy, Toxicology, Gastroenterology, chemistry.chemical_compound, Risk Factors, Antiretroviral Therapy, Highly Active, Internal medicine, Humans, Medicine, Pharmacology (medical), Longitudinal Studies, Renal Insufficiency, Tenofovir, Retrospective Studies, Pharmacology, Creatinine, Kidney, Univariate analysis, business.industry, Incidence, Incidence (epidemiology), Surgery, medicine.anatomical_structure, chemistry, Spain, Toxicity, Female, Ritonavir, business, Complication, Glomerular Filtration Rate, medicine.drug |
| الوصف: | Background Since the beginning of highly active antiretroviral therapy utilization, the association of renal impairment with treatment toxicity is more prevalent. Tenofovir disoproxil fumarate (TDF) side effects include renal toxicity. Objective To assess the incidence of renal damage in human immunodeficiency virus (HIV)-positive patients treated with TDF and to identify associated potential risk factors. Setting A public university tertiary 450-beds hospital in Spain. Method Retrospective, longitudinal observational study that included adult HIV-1-infected patients treated with TDF. Patient´s treated with TDF from January 2010 to December 2012 were included. Patient follow-up started when initiating treatment with TDF up until either end of treatment or end of study (July 31, 2013). The estimated glomerular filtration rate was calculated using the four-variable modification of diet in renal disease. Renal toxicity was classified as moderate [estimated glomerular filtration rate (eGFR) |
| تدمد: | 2210-7711 2210-7703 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e425c47349bb218a3049e55a3c7d9759 https://doi.org/10.1007/s11096-015-0132-1 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e425c47349bb218a3049e55a3c7d9759 |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 22107711 22107703 |
|---|