Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure
| العنوان: | Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure |
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| المؤلفون: | Lukas A. J. Rammeloo, Tim Takken, Gabriëlle G. van Iperen, Gideon J. du Marchie Sarvaas, Michiel Dalinghaus, Ad P. C. M. Backx, Daniël H. K. Flipse, Ronald B. Tanke, Susanna L. den Boer, Willem A. Helbing, Arend D. J. ten Harkel, Marijke van der Meulen |
| المساهمون: | Pediatrics, Pediatric surgery, ACS - Heart failure & arrhythmias, Paediatric Cardiology |
| المصدر: | Pediatric Cardiology, 38(3), 465-471. Springer New York Pediatric Cardiology, 38(3), 465. Springer New York Pediatric cardiology, 38(3), 465-471. SPRINGER den Boer, S L, Flipse, D H K, van der Meulen, M H, Backx, A P C M, du Marchie Sarvaas, G J, Ten Harkel, A D J, van Iperen, G G, Rammeloo, L A J, Tanke, R B, Helbing, W A, Takken, T & Dalinghaus, M 2017, ' Six-Minute Walk Test as a Predictor for Outcome in Children with Dilated Cardiomyopathy and Chronic Stable Heart Failure ', Pediatric Cardiology, vol. 38, no. 3, pp. 465-471 . https://doi.org/10.1007/s00246-016-1536-y Pediatric Cardiology, 38(3), 465-471 Pediatric Cardiology, 38, 3, pp. 465-471 Pediatric Cardiology Pediatric cardiology, 38(3), 465-471. Springer New York Pediatric Cardiology, 38, 465-471 |
| بيانات النشر: | SPRINGER, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, Exercise test, medicine.medical_treatment, Dilated cardiomyopathy, Kaplan-Meier Estimate, 030204 cardiovascular system & hematology, Pediatrics, 0302 clinical medicine, Risk Factors, Interquartile range, ADOLESCENTS, Prospective Studies, 030212 general & internal medicine, Child, Netherlands, Heart transplantation, Exercise Tolerance, 6-minute walk test, Hazard ratio, Prognosis, 3. Good health, Multicenter Study, Cardiology, SURVIVAL, Female, Original Article, Cardiology and Cardiovascular Medicine, Cardiomyopathy, Dilated, medicine.medical_specialty, Adolescent, Walk Test, Lower risk, 03 medical and health sciences, PEAK OXYGEN-UPTAKE, Internal medicine, medicine, Journal Article, Humans, Pediatrics, Perinatology, and Child Health, INDICATOR, Proportional Hazards Models, Heart Failure, Proportional hazards model, business.industry, TRANSPLANTATION, Other Research Radboud Institute for Health Sciences [Radboudumc 0], CONSUMPTION, CARE, medicine.disease, DYSFUNCTION, Transplantation, ROC Curve, CLINICAL-PRACTICE, Heart failure, Chronic Disease, Pediatrics, Perinatology and Child Health, Heart Transplantation, business |
| الوصف: | Contains fulltext : 170591.pdf (Publisher’s version ) (Open Access) Cardiopulmonary exercise testing is an important tool to predict prognosis in children and adults with heart failure. A much less sophisticated exercise test is the 6 min walk test, which has been shown an independent predictor for morbidity and mortality in adults with heart failure. Therefore, we hypothesized that the 6 min walk test could be predictive for outcome in children with dilated cardiomyopathy. We prospectively included 49 children with dilated cardiomyopathy >/=6 years who performed a 6 min walk test. Median age was 11.9 years (interquartile range [IQR] 7.4-15.1), median time after diagnosis was 3.6 years (IQR 0.6-7.4). The 6 min walk distance was transformed to a percentage of predicted, using age- and gender-specific norm values (6MWD%). For all patients, mean 6MWD% was 70 +/- 21%. Median follow-up was 33 months (IQR 14-50). Ten patients reached the combined endpoint of death or heart transplantation. Using univariable Cox regression, a higher 6MWD% resulted in a lower risk of death or transplantation (hazard ratio 0.95 per percentage increase, p = 0.006). A receiver operating characteristic curve was generated to define the optimal threshold to identify patients at highest risk for an endpoint. Patients with a 6MWD% < 63% had a 2 year transplant-free survival of 73%, in contrast to a transplant-free survival of 92% in patients with a 6MWD% >/= 63% (p = 0.003). In children with dilated cardiomyopathy, the 6 min walk test is a simple and feasible tool to identify children with a higher risk of death or heart transplantation. |
| وصف الملف: | application/pdf; image/pdf |
| اللغة: | English |
| تدمد: | 0172-0643 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e45f32956ded993ce2a854ff8a0b902e https://research.rug.nl/en/publications/93d0b417-06d2-4119-81b6-aa2d71787d30 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e45f32956ded993ce2a854ff8a0b902e |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 01720643 |
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