Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study
| العنوان: | Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study |
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| المؤلفون: | Mari Yoshida, Teppei Komatsu, Monika Bradl, Kiyotaka Nakamagoe, Tatsuro Misu, Ichiro Nakashima, Masashi Aoki, Hiroshi Kuroda, Kazuo Fujihara, Koichi Narikawa, Hiroyoshi Suzuki, Toshimasa Ikeda, Hans Lassmann, Hiroya Nishida, Kimihiko Kaneko, Takashi Komori, Morinobu Seki, Yoshiki Takai, Shuhei Nishiyama, Hirohiko Ono, Norio Chihara, Satoko Tsuchida, Toshiyuki Takahashi |
| المصدر: | Brain. 143:1431-1446 |
| بيانات النشر: | Oxford University Press (OUP), 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Adolescent, Myelitis, Demyelinating Autoimmune Diseases, CNS, Autoantigens, Myelin oligodendrocyte glycoprotein, Young Adult, 03 medical and health sciences, Myelin, 0302 clinical medicine, medicine, Demyelinating disease, Humans, Optic neuritis, Child, Autoantibodies, Neuromyelitis optica, biology, business.industry, Multiple sclerosis, Brain, Middle Aged, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, Acute disseminated encephalomyelitis, biology.protein, Female, Myelin-Oligodendrocyte Glycoprotein, Neurology (clinical), business, 030217 neurology & neurosurgery |
| الوصف: | Conformation-sensitive antibodies against myelin oligodendrocyte glycoprotein (MOG) are detectable in patients with optic neuritis, myelitis, opticomyelitis, acute or multiphasic disseminated encephalomyelitis (ADEM/MDEM) and brainstem/cerebral cortical encephalitis, but are rarely detected in patients with prototypic multiple sclerosis. So far, there has been no systematic study on the pathological relationship between demyelinating lesions and cellular/humoral immunity in MOG antibody-associated disease. Furthermore, it is unclear whether the pathomechanisms of MOG antibody-mediated demyelination are similar to the demyelination patterns of multiple sclerosis, neuromyelitis optica spectrum disorders (NMOSD) with AQP4 antibody, or ADEM. In this study, we immunohistochemically analysed biopsied brain tissues from 11 patients with MOG antibody-associated disease and other inflammatory demyelinating diseases. Patient median onset age was 29 years (range 9–64), and the median interval from attack to biopsy was 1 month (range 0.5–96). The clinical diagnoses were ADEM (n = 2), MDEM (n = 1), multiple brain lesions without encephalopathy (n = 3), leukoencephalopathy (n = 3) and cortical encephalitis (n = 2). All these cases had multiple/extensive lesions on MRI and were oligoclonal IgG band-negative. Most demyelinating lesions in 10 of 11 cases showed a perivenous demyelinating pattern previously reported in ADEM (153/167 lesions) and a fusion pattern (11/167 lesions) mainly in the cortico-medullary junctions and white matter, and only three lesions in two cases showed confluent demyelinated plaques. In addition, 60 of 167 demyelinating lesions (mainly in the early phase) showed MOG-dominant myelin loss, but relatively preserved oligodendrocytes, which were distinct from those of AQP4 antibody-positive NMOSD exhibiting myelin-associated glycoprotein-dominant oligodendrogliopathy. In MOG antibody-associated diseases, MOG-laden macrophages were found in the perivascular spaces and demyelinating lesions, and infiltrated cells were abundant surrounding multiple blood vessels in and around the demyelinating lesions, mainly consisting of macrophages (CD68; 1814 ± 1188 cells/mm2), B cells (CD20; 468 ± 817 cells/mm2), and T cells (CD3; 2286 ± 1951 cells/mm2), with CD4-dominance (CD4+ versus CD8+; 1281 ± 1196 cells/mm2 versus 851 ± 762 cells/mm2, P |
| تدمد: | 1460-2156 0006-8950 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46bfcb2b668eb05ca0b6958aa363618 https://doi.org/10.1093/brain/awaa102 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e46bfcb2b668eb05ca0b6958aa363618 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14602156 00068950 |
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