Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells
| العنوان: | Inhibitory effect of desoxyrhaponticin and rhaponticin, two natural stilbene glycosides from the Tibetan nutritional food Rheum tanguticum Maxim. ex Balf., on fatty acid synthase and human breast cancer cells |
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| المؤلفون: | Xiaofeng Ma, Ping Li, Weixi Tian, Xiaoyan Wang |
| المصدر: | Food Funct.. 5:251-256 |
| بيانات النشر: | Royal Society of Chemistry (RSC), 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Cell Survival, Down-Regulation, Apoptosis, Breast Neoplasms, Pharmacology, Tibet, chemistry.chemical_compound, Glucosides, Cell Line, Tumor, Stilbenes, medicine, Humans, Rhaponticin, Enzyme Inhibitors, Rheum, Cell Proliferation, chemistry.chemical_classification, biology, Plant Extracts, Fatty Acids, Glycoside, Cancer, General Medicine, medicine.disease, Fatty acid synthase, Enzyme, chemistry, Biochemistry, Cell culture, Cancer cell, biology.protein, Female, Fatty Acid Synthases, Food Science |
| الوصف: | Fatty acid synthase (FAS) has attracted more and more attention as a potential target for cancer treatment. Natural FAS inhibitors are emerging as potential therapeutic agents to treat cancer. Rheum tanguticum Maxim. ex Balf. (rhubarb) is a traditional Chinese nutritional food and has been reported to possess a variety of biological activities, including the ability to induce the apoptosis of cancer cells. This study indicates that desoxyrhaponticin (DC) and rhaponticin (RC), two stilbene glycosides from rhubarb, could be considered as promising FAS inhibitors. We found that both DC and RC could inhibit intracellular FAS activity and downregulate FAS expression in human breast cancer MCF-7 cells. In addition, the apoptotic effect of DC on human cancer cells was announced for the first time. Since FAS plays a key role in the biosynthesis pathway of fatty acids in cancer cells, these findings suggest that DC has potential applications in the prevention and treatment of cancer. |
| تدمد: | 2042-650X 2042-6496 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4932b09fed2a50bb6bb9c2281cbdb79 https://doi.org/10.1039/c3fo60484e |
| رقم الأكسشن: | edsair.doi.dedup.....e4932b09fed2a50bb6bb9c2281cbdb79 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2042650X 20426496 |
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