Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain
| العنوان: | Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain |
|---|---|
| المؤلفون: | Sarah N. Benke, Amber R. Syage, Audrey L. Park, Nicole N. Chmielewski, Charles L. Limoli, Munjal M. Acharya, Vipan K. Parihar, Ning Ru, Barrett D. Allen, Vahan Martirosian, Janet E. Baulch, Erich Giedzinski |
| المصدر: | Proceedings of the National Academy of Sciences of the United States of America, vol 113, iss 17 Baulch, JE; Acharya, MM; Allen, BD; Ru, N; Chmielewski, NN; Martirosian, V; et al.(2016). Cranial grafting of stem cell-derived microvesicles improves cognition and reduces neuropathology in the irradiated brain. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 113(17), 4836-4841. doi: 10.1073/pnas.1521668113. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/1187f13x |
| بيانات النشر: | eScholarship, University of California, 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Male, Nude, dendritic complexity, Neocortex, Hippocampus, neuroinflammation, Neural Stem Cells, Genes, Reporter, Cell-Derived Microparticles, Stem Cell Research - Nonembryonic - Human, Medicine, 2.1 Biological and endogenous factors, Brain Damage, Chronic, Aetiology, Cells, Cultured, Cancer, Multidisciplinary, Cultured, Microvesicle, Biological Sciences, Amygdala, Neural stem cell, Radiation Injuries, Experimental, Neurological, Heterografts, Brain Damage, Chronic, Microglia, Stem cell, microvesicles, Cells, Neuropathology, Neuroprotection, 03 medical and health sciences, Rats, Nude, Experimental, Rare Diseases, Animals, Humans, radiation-induced cognitive dysfunction, Habituation, Psychophysiologic, Radiation Injuries, Reporter, Neuroinflammation, Psychophysiologic, Transplantation, business.industry, Neurosciences, Stem Cell Research, Microvesicles, Rats, Brain Disorders, Brain Cancer, 030104 developmental biology, human neural stem cells, Genes, Habituation, Cranial Irradiation, business, Cognition Disorders, Neuroscience |
| الوصف: | Cancer survivors face a variety of challenges as they cope with disease recurrence and a myriad of normal tissue complications brought on by radio- and chemotherapeutic treatment regimens. For patients subjected to cranial irradiation for the control of CNS malignancy, progressive and debilitating cognitive dysfunction remains a pressing unmet medical need. Although this problem has been recognized for decades, few if any satisfactory long-term solutions exist to resolve this serious unintended side effect of radiotherapy. Past work from our laboratory has demonstrated the neurocognitive benefits of human neural stem cell (hNSC) grafting in the irradiated brain, where intrahippocampal transplantation of hNSC ameliorated radiation-induced cognitive deficits. Using a similar strategy, we now provide, to our knowledge, the first evidence that cranial grafting of microvesicles secreted from hNSC affords similar neuroprotective phenotypes after head-only irradiation. Cortical- and hippocampal-based deficits found 1 mo after irradiation were completely resolved in animals cranially grafted with microvesicles. Microvesicle treatment was found to attenuate neuroinflammation and preserve host neuronal morphology in distinct regions of the brain. These data suggest that the neuroprotective properties of microvesicles act through a trophic support mechanism that reduces inflammation and preserves the structural integrity of the irradiated microenvironment. |
| وصف الملف: | application/pdf |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4cf20512f5d23e4b1897edaaae43dd8 https://escholarship.org/uc/item/1187f13x |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e4cf20512f5d23e4b1897edaaae43dd8 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |