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Syntheses of trans-5- Oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-Oxo-hexahydro-furo[3,2-b]pyrroles (Pyrrolidine trans-Lactams and trans-Lactones): New Pharmacophores for Elastase Inhibition

التفاصيل البيبلوغرافية
العنوان: Syntheses of trans-5- Oxo-hexahydro-pyrrolo[3,2-b]pyrroles and trans-5-Oxo-hexahydro-furo[3,2-b]pyrroles (Pyrrolidine trans-Lactams and trans-Lactones): New Pharmacophores for Elastase Inhibition
المؤلفون: Michael S. Anson, Keith Mills, Simon J. F. Macdonald, Doreen M. Buckley, Richard J. Upton, Lee Andrew Harrison, Catherine Risley, David J. Belton, Michael Dennis Dowle, Christopher R Molloy, Julie E. Spooner, Robin A.J. Smith
المصدر: Journal of Medicinal Chemistry. 41:3919-3922
بيانات النشر: American Chemical Society (ACS), 1998.
سنة النشر: 1998
مصطلحات موضوعية: chemistry.chemical_classification, Serine Proteinase Inhibitors, Lactams, biology, Bicyclic molecule, Neutrophils, Stereochemistry, Chemical synthesis, Piperazines, Pyrrolidine, Lactones, Structure-Activity Relationship, chemistry.chemical_compound, chemistry, Enzyme inhibitor, Drug Discovery, biology.protein, Lactam, Azetidines, Humans, Molecular Medicine, Structure–activity relationship, Enantiomer, Leukocyte Elastase, Lactone
تدمد: 1520-4804
0022-2623
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4e2b3a2e78fe6a3c8dc40e7d1221df3
https://doi.org/10.1021/jm981026s
رقم الأكسشن: edsair.doi.dedup.....e4e2b3a2e78fe6a3c8dc40e7d1221df3
قاعدة البيانات: OpenAIRE
الوصف
تدمد:15204804
00222623