IPMNs with co-occurring invasive cancers: neighbours but not always relatives
| العنوان: | IPMNs with co-occurring invasive cancers: neighbours but not always relatives |
|---|---|
| المؤلفون: | Gemma Lionheart, David L. Masica, Waki Hosoda, Matthew J. Weiss, John L. Cameron, Jun Yu, Jin He, Christopher L. Wolfgang, Michael Goggins, Lodewijk A.A. Brosens, Michaël Noë, Nicholas J. Roberts, Rachel Karchin, Antonio Pea, Peter Chianchiano, Georgios Gemenetzis, Catherine G Fischer, Martin A. Makary, Laura D. Wood, Matthäus Felsenstein, Ralph H. Hruban, Vincent P. Groot |
| المصدر: | Gut, 67(9), 1561. BMJ Publishing Group |
| بيانات النشر: | BMJ, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, endocrine system diseases, pancreatic cancer, Severity of Illness Index, Gastroenterology, 0302 clinical medicine, GTP-Binding Protein alpha Subunits, Gs, Prevalence, Smad4 Protein, Oncogene Proteins, Invasive carcinoma, Colloid Carcinomas, Middle Aged, Adenocarcinoma, Mucinous, DNA-Binding Proteins, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, carcinogenesis, Carcinoma, Pancreatic Ductal, medicine.medical_specialty, Pancreatic ductal adenocarcinoma, Ubiquitin-Protein Ligases, Mutation, Missense, cancer genetics, Sensitivity and Specificity, 03 medical and health sciences, Co occurring, Predictive Value of Tests, Internal medicine, Molecular genetics, Pancreatic cancer, Biomarkers, Tumor, Chromogranins, medicine, Carcinoma, Humans, Neoplasm Invasiveness, Aged, Retrospective Studies, Genetic heterogeneity, business.industry, Genes, p16, mutations, medicine.disease, Survival Analysis, Carcinoma, Papillary, United States, Pancreatic Neoplasms, molecular genetics, Mutation, business, Follow-Up Studies |
| الوصف: | ObjectiveIntraductal papillary mucinous neoplasms (IPMNs) are precursor lesions that can give rise to invasive pancreatic carcinoma. Although approximately 8% of patients with resected pancreatic ductal adenocarcinoma have a co-occurring IPMN, the precise genetic relationship between these two lesions has not been systematically investigated.DesignWe analysed all available patients with co-occurring IPMN and invasive intrapancreatic carcinoma over a 10-year period at a single institution. For each patient, we separately isolated DNA from the carcinoma, adjacent IPMN and distant IPMN and performed targeted next generation sequencing of a panel of pancreatic cancer driver genes. We then used the identified mutations to infer the relatedness of the IPMN and co-occurring invasive carcinoma in each patient.ResultsWe analysed co-occurring IPMN and invasive carcinoma from 61 patients with IPMN/ductal adenocarcinoma as well as 13 patients with IPMN/colloid carcinoma and 7 patients with IPMN/carcinoma of the ampullary region. Of the patients with co-occurring IPMN and ductal adenocarcinoma, 51% were likely related. Surprisingly, 18% of co-occurring IPMN and ductal adenocarcinomas were likely independent, suggesting that the carcinoma arose from an independent precursor. By contrast, all colloid carcinomas were likely related to their associated IPMNs. In addition, these analyses showed striking genetic heterogeneity in IPMNs, even with respect to well-characterised driver genes.ConclusionThis study demonstrates a higher prevalence of likely independent co-occurring IPMN and ductal adenocarcinoma than previously appreciated. These findings have important implications for molecular risk stratification of patients with IPMN. |
| وصف الملف: | image/pdf |
| تدمد: | 1468-3288 0017-5749 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f290064435fbaaea5abd397c643ba1 https://doi.org/10.1136/gutjnl-2017-315062 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e4f290064435fbaaea5abd397c643ba1 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14683288 00175749 |
|---|