Enhanced Biological Imaging via Aggregation-Induced Emission Active Porous Organic Cages
| العنوان: | Enhanced Biological Imaging via Aggregation-Induced Emission Active Porous Organic Cages |
|---|---|
| المؤلفون: | Jinqiao Dong, Yutong Pan, Kuiwei Yang, Yi Di Yuan, Vanessa Wee, Shidang Xu, Yuxiang Wang, Jianwen Jiang, Bin Liu, Dan Zhao |
| المصدر: | ACS Nano. 16:2355-2368 |
| بيانات النشر: | American Chemical Society (ACS), 2022. |
| سنة النشر: | 2022 |
| مصطلحات موضوعية: | Diagnostic Imaging, General Engineering, General Physics and Astronomy, General Materials Science, Porosity, Metal-Organic Frameworks |
| الوصف: | Porous organic cages (POCs) have many advantages, including superior microenvironments, good monodispersity, and shape homogeneity, excellent molecular solubility, high chemical stability, and intriguing host-guest chemistry. These properties enable POCs to overcome the limitations of extended porous networks such as metal-organic frameworks (MOFs) and covalent organic frameworks (COFs). However, the applications of POCs in bioimaging remain limited due to the problems associated with their rigid and hydrophobic structures, thus leading to strong aggregation-caused quenching (ACQ) in aqueous biological media. To address this challenge, we report the preparation of aggregation-induced emission (AIE)-active POCs capable of stimuli responsiveness for enhanced bioimaging. We rationally design a hydrophilic, structurally flexible tetraphenylethylene (TPE)-based POC that is almost entirely soluble in aqueous solutions. This POC's conformationally flexible superstructure allows the dynamic rotation of the TPE-based phenyl rings, thus endowing impressive AIE characteristics for responses to environmental changes such as temperature and viscosity. We employ these notable features in the bioimaging of living cells and obtain good performance, demonstrating that the present AIE-active POCs are suitable candidates for further biological applications. |
| تدمد: | 1936-086X 1936-0851 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e574a526b62311ded9855f8ad39b8b72 https://doi.org/10.1021/acsnano.1c08605 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e574a526b62311ded9855f8ad39b8b72 |
| قاعدة البيانات: | OpenAIRE |
Find this issue from the American Chemical Society | تدمد: | 1936086X 19360851 |
|---|