Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium
| العنوان: | Canonical Wnt Signaling Drives Tumor-Like Lesions from Sox2-Positive Precursors of the Murine Olfactory Epithelium |
|---|---|
| المؤلفون: | Annika K. Wefers, Nils W. Engel, Julia E. Neumann, Daniel Merk, Julia Ahlfeld, Ulrich Schüller, Jasmin Ohli |
| المصدر: | PLoS ONE, Vol 11, Iss 11, p e0166690 (2016) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2016. |
| سنة النشر: | 2016 |
| مصطلحات موضوعية: | 0301 basic medicine, Pathology, lcsh:Medicine, Epithelium, Mice, 0302 clinical medicine, Cell Signaling, Animal Cells, Medicine and Health Sciences, Phosphorylation, lcsh:Science, Wnt Signaling Pathway, beta Catenin, WNT Signaling Cascade, Staining, Multidisciplinary, Stem Cells, Stomach, Wnt signaling pathway, Cell Staining, LRP6, LRP5, Animal Models, Signaling Cascades, Cell biology, medicine.anatomical_structure, Oncology, 030220 oncology & carcinogenesis, Female, Anatomy, Cellular Types, Stem cell, Research Article, Signal Transduction, medicine.medical_specialty, Nose Neoplasms, Mice, Transgenic, Mouse Models, Biology, Research and Analysis Methods, 03 medical and health sciences, Model Organisms, Olfactory Mucosa, SOX2, medicine, Animals, Immunohistochemistry Techniques, Differentiated Tumors, Cell Proliferation, Hyperplasia, SOXB1 Transcription Factors, lcsh:R, Biology and Life Sciences, Cancers and Neoplasms, Cell Biology, Enzyme Activation, Wnt Proteins, Histochemistry and Cytochemistry Techniques, Gastrointestinal Tract, Tamoxifen, Biological Tissue, 030104 developmental biology, Specimen Preparation and Treatment, Immunologic Techniques, lcsh:Q, Olfactory ensheathing glia, Digestive System, Olfactory epithelium |
| الوصف: | Canonical Wnt signaling is known to promote proliferation of olfactory stem cells. In order to investigate the effects of a constitutive activation of Wnt signaling in Sox2-positive precursor cells of the olfactory epithelium, we used transgenic mice that allowed an inducible deletion of exon 3 of the Ctnnb1 gene, which is responsible for the phosphorylation and degradation of Ctnnb1 protein. After induction of aberrant Wnt activation by Ctnnb1 deletion at embryonic day 14, such mice developed tumor-like lesions in upper parts of the nasal cavity. We still observed areas of epithelial hyperplasia within the olfactory epithelium following early postnatal Wnt activation, but the olfactory epithelial architecture remained unaffected in most parts when Wnt was activated at postnatal day 21 or later. In summary, our results suggest an age-dependent tumorigenic potential of aberrant Wnt signaling in the olfactory epithelium of mice. |
| اللغة: | English |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e591c69a4aba5b2b40186b26c57fb674 http://europepmc.org/articles/PMC5130221?pdf=render |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e591c69a4aba5b2b40186b26c57fb674 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
|---|