Brain Microbleeds and Global Cognitive Function in Adults Without Neurological Disorder
| العنوان: | Brain Microbleeds and Global Cognitive Function in Adults Without Neurological Disorder |
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| المؤلفون: | Tatsumi Hirotsu, Yusuke Yakushiji, Makoto Eriguchi, Junko Nakajima, Satomi Yakushiji, Etsuo Horikawa, Yusuke Nanri, Masanori Nishiyama, Megumi Hara, Yasuo Kuroda, Akira Uchino |
| المصدر: | Stroke. 39:3323-3328 |
| بيانات النشر: | Ovid Technologies (Wolters Kluwer Health), 2008. |
| سنة النشر: | 2008 |
| مصطلحات موضوعية: | Adult, Male, Pediatrics, medicine.medical_specialty, Hyperlipidemias, Comorbidity, Neurological disorder, Neuropsychological Tests, Central nervous system disease, Diabetes Mellitus, medicine, Humans, Mass Screening, Prospective Studies, Stroke, Aged, Cerebral Hemorrhage, Aged, 80 and over, Advanced and Specialized Nursing, Univariate analysis, Mini–Mental State Examination, medicine.diagnostic_test, business.industry, Dementia, Vascular, Smoking, Cognitive disorder, Cognition, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Hyperintensity, Surgery, Hypertension, Female, Neurology (clinical), Cognition Disorders, Cardiology and Cardiovascular Medicine, business |
| الوصف: | Background and Purpose— Increasing attention has been paid to associations between cognitive dysfunction and brain microbleeds (MBs). Because all previous studies have investigated patients with neurological disorders, we examined subjects without neurological disorder in order to clarify pathogenic relationships. Methods— A total of 518 consecutive adults without neurological disorder who had undergone health-screening tests of the brain were studied prospectively. Gradient-echo T2*-weighted MRI using a 1.5-T system was used to detect MBs. The Mini-Mental State Examination (MMSE) was administered to determine cognitive functions. MMSE scores 1.5 SDs below the age-related mean were regarded as subnormal. Results— MBs were found in 35 subjects (6.8%). MMSE score 1.5 SDs below the age-related mean in 34 subjects (6.6%). Univariate analysis showed presence and number of MBs, short duration of education, and severe white matter hyperintensities as significantly associated with subnormal scores. In logistic regression analysis, presence of MBs (odds ratio [OR], 5.44; 95% CI, 1.83 to 16.19) and number of MBs (OR, 1.32; 95% CI, 1.04 to 1.68) still displayed significant associations with MMSE score 1.5 SDs below the age-related mean. Among MMSE subscores, “attention and calculation” was significantly lower in MB-positive subjects ( P =0.017). Conclusions— MBs appear to be primarily associated with global cognitive dysfunction. |
| تدمد: | 1524-4628 0039-2499 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e59d5da6a1b794e3fa6b8fd9f0ab28e9 https://doi.org/10.1161/strokeaha.108.516112 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e59d5da6a1b794e3fa6b8fd9f0ab28e9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15244628 00392499 |
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