The Value of SSTR2 Receptor-Targeted PET/CT in Proton Irradiation of Grade I Meningioma
| العنوان: | The Value of SSTR2 Receptor-Targeted PET/CT in Proton Irradiation of Grade I Meningioma |
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| المؤلفون: | Eugen B. Hug, Razvan Galalae, Carola Lütgendorf-Caucig, Slavisa Tubin, Birgit Flechl, Marta Mumot, Maciej J. Pelak |
| المصدر: | Cancers, Vol 13, Iss 4707, p 4707 (2021) Cancers Volume 13 Issue 18 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Cancer Research, PET-CT, Particle therapy, business.industry, PET/CT, medicine.medical_treatment, Planning target volume, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, meningioma, Article, Meningioma, Oncology, DOTA, medicine, proton therapy, Somatostatin receptor 2, business, Radiation treatment planning, Nuclear medicine, Proton therapy, Grade I Meningioma, RC254-282 |
| الوصف: | Grade I meningioma is the most common intracranial tumor in adults. The standard imaging for its radiation treatment planning is MRI, and [68Ga]1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA)-conjugated PET/CT can further improve delineation. We investigated the impact of PET/CT on interobserver variability in identifying the tumor in 30 anonymized patients. Four radiation oncologists independently contoured residual tumor volume, first using only MRI and subsequently with the addition of PET/CT. Conformity indices (CIs) were calculated between common volumes, observer pairs and compared to the volumes previously used. Overall, 29/30 tumors (96.6%) showed [68Ga]Ga-DOTA avidity. With help of PET/CT, the participants identified six cases with new lesions not recognized in MRI, including two where new findings would critically alter the target volume used for radiation. The PET/CT-aided series demonstrated superior conformity, as compared to MRI-only between observer pairs (median CI = 0.58 vs. 0.49 p = 0.002), common volumes (CI = 0.34 vs. 0.29 p = 0.002) and matched better the reference volumes actually used for patient treatment (CI = 0.55 vs. 0.39 p = 0.008). Cis in the PET/CT-aided series were lower for meningiomas outside of the skull base (0.2 vs. 0.44 p = 0.03). We conclude that SSTR2 receptor-targeted PET/CT is a valuable tool for planning particle therapy of incompletely resected meningioma. It serves both as a workup procedure and an aid for delineation process that reduces the likelihood of marginal misses. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| تدمد: | 2072-6694 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c42e3c35c1578def2b744497dcefd0 https://www.mdpi.com/2072-6694/13/18/4707 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e5c42e3c35c1578def2b744497dcefd0 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726694 |
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