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Multimodal Tandem Mass Spectrometry Techniques for the Analysis of Phosphopeptides

التفاصيل البيبلوغرافية
العنوان: Multimodal Tandem Mass Spectrometry Techniques for the Analysis of Phosphopeptides
المؤلفون: Johanna Paris, Alina Theisen, Bryan P. Marzullo, Anisha Haris, Tomos E. Morgan, Mark P. Barrow, John O’Hara, Peter B. O’Connor
المصدر: Journal of the American Society for Mass Spectrometry. 33:1126-1133
بيانات النشر: American Chemical Society (ACS), 2022.
سنة النشر: 2022
مصطلحات موضوعية: Phosphopeptides, Fourier Analysis, Tandem Mass Spectrometry, Structural Biology, Electrons, QD, Cyclotrons, Spectroscopy
الوصف: Collisionally activated dissociation (CAD), infrared multiphoton dissociation (IRMPD), ultraviolet photodissociation (UVPD), electron capture dissociation and electron detachment dissociation (EDD) experiments were conducted on a set of phosphopeptides, in a Fourier transform ion cyclotron resonance mass spectrometer. The fragmentation patterns were compared and varied according to the fragmentation mechanisms and the composition of the peptides. CAD and IRMPD produced similar fragmentation profiles of the phosphopeptides, while UVPD produced a large number of complementary fragments. Electron-based dissociation techniques displayed lower fragmentation efficiencies, despite retaining the labile phosphate group, and drastically different fragmentation profiles. EDD produced complex spectra whose interpretation proved challenging.\ud \ud
وصف الملف: application/pdf
تدمد: 1879-1123
1044-0305
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d59a55902d800ab16a07e17dd6f8dd
https://doi.org/10.1021/jasms.1c00353
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....e5d59a55902d800ab16a07e17dd6f8dd
قاعدة البيانات: OpenAIRE
الوصف
تدمد:18791123
10440305