Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis
| العنوان: | Plasma arginine, citrulline, and ornithine kinetics in adults, with observations on nitric oxide synthesis |
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| المؤلفون: | Steven R. Tannenbaum, Teresa deRojas-Walker, J. Vogt, Leticia Castillo, Alfred M. Ajami, M. Sanchez, Vernon R. Young, T E Chapman |
| المصدر: | American Journal of Physiology-Endocrinology and Metabolism. 268:E360-E367 |
| بيانات النشر: | American Physiological Society, 1995. |
| سنة النشر: | 1995 |
| مصطلحات موضوعية: | Adult, Male, Ornithine, medicine.medical_specialty, Arginine, Physiology, Endocrinology, Diabetes and Metabolism, Nitric Oxide, Nitric oxide, chemistry.chemical_compound, Nitrate, Physiology (medical), Internal medicine, medicine, Citrulline, Homeostasis, Humans, Nitrogen Isotopes, Fasting, Metabolism, Diet, Kinetics, Endocrinology, chemistry, Leucine |
| الوصف: | The plasma fluxes of ornithine (Orn), arginine (Arg), and citrulline (Cit) and rate of conversion of labeled ornithine-to-citrulline (QOrn-->Cit) were estimated in six healthy adult men receiving an arginine-rich or arginine-free L-amino acid-based diet, each for 6 days. On day 7 an 8-h (3-h fast, 5-h fed) primed continuous intravenous infusion of L-[guanido-15N,15N] arginine, L-[ureido-13C]citrulline, L-[5,5,2H2]ornithine, and L-[5,5,5-2H3]leucine was conducted. Mean citrulline fluxes (mumol.kg-1.h-1) were 10.4-13.6 for the various conditions and/or diets and remained unchanged (P > 0.05). Arginine flux was lowered (P < 0.01) by 38% for fed state during arginine-free period. Ornithine fluxes for arginine-rich were (P < 0.01) reduced with the arginine-free diet. Rates of QOrn-->Cit declined by 30% (P < .05) during the fed arginine-free period. Short-term restriction in the dietary supply of arginine did not alter the rate of whole body nitric oxide synthesis. One subject showed a very high output of nitrate on arginine-free diet (6 times average for remaining subjects). |
| تدمد: | 1522-1555 0193-1849 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6078c17a391705f411620b7320e765c https://doi.org/10.1152/ajpendo.1995.268.2.e360 |
| رقم الأكسشن: | edsair.doi.dedup.....e6078c17a391705f411620b7320e765c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221555 01931849 |
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