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Hypoechogenicity of brainstem raphe correlates with depression in migraine patients

التفاصيل البيبلوغرافية
العنوان: Hypoechogenicity of brainstem raphe correlates with depression in migraine patients
المؤلفون: Xue-Gong Shi, Wei-Wei Tao, Yu Wang, Jie Shen, Xin-Ting Cai
المصدر: The Journal of Headache and Pain
The Journal of Headache and Pain, Vol 20, Iss 1, Pp 1-6 (2019)
سنة النشر: 2019
مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Aura, Ultrasonography, Doppler, Transcranial, Migraine Disorders, lcsh:Medicine, Hospital Anxiety and Depression Scale, Gastroenterology, Brainstem raphe, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Internal medicine, Medicine, Humans, 030212 general & internal medicine, Depression (differential diagnoses), Depressive Disorder, Third ventricle, Raphe, business.industry, Depression, lcsh:R, Echogenicity, Hamilton Rating Scale for Depression, General Medicine, Middle Aged, medicine.disease, Hyperechogenicity, Hypoechogenicity, Substantia Nigra, Anesthesiology and Pain Medicine, medicine.anatomical_structure, Migraine, Case-Control Studies, Migraine without aura, Transcranial sonography, Raphe Nuclei, Female, Neurology (clinical), business, 030217 neurology & neurosurgery, Research Article
الوصف: Background Brainstem raphe (BR) hypoechogenicity in transcranial sonography (TCS) has been depicted in patients with major depression (MD) and in depressed patients with different neurodegenerative diseases. But, up to date, the association of BR alterations in TCS with depression in migraineurs has never been reported. This study was to investigate the possible role of BR examination via TCS in migraineurs with depression. Methods Forty two migraine without aura (MwoA) patients and 40 healthy controls were recruited. Echogenicity of lentiform nuclei (LN), caudate nuclei (CN), substantia nigra (SN) and brainstem raphe (BR) and width of the frontal horns of the lateral ventricles and the third ventricle were assessed with TCS. The diagnosis of depression was based on the criteria of the Diagnostic and Statistical Manual of Mental Disorders IV (DSM –IV), and the severity of depression was measured by Hamilton Rating Scale for Depression (HAM-D) and Hospital Anxiety and Depression Scale depression subscale (HADS-D). Results There were no significant differences between migraineurs and controls in the width of frontal horn of the lateral ventricle (p = 0.955), width of third ventricle (p = 0.129) as well as in the echogenicity of SN (p = 0.942), CN (p = 0.053), LN (p = 0.052) and BR (p = 0.677). Here, it seems that more migraineurs were detected with increased echogenecity of CN and LN compared with controls (33.3% versus 15.0% for CN, 19.0% versus 5.0% for LN) though they had no statistical significance. Patients with hypoechogenic BR had significantly higher HAM-D and HADS-D scores than those with normal BR signal (p = 0.000 for both HAM-D and HADS-D), and most (83.33%) migraineurs with depression exhibited hypoechogenic raphe but none (0.00%) of the migraineurs without depression exhibited hypoechogenic raphe (p = 0.000). Conlusions TCS signal alteration of BR can be a biomarker for depression in migraine but it is not associated with migraine headache itself. LN and CN alterations in TCS may reflect a potential role of them in the pathogenesis of migraine, which needs to be further elucidated.
تدمد: 1129-2377
URL الوصول: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e612edc8842af63a4c0ed5e05856aeb4
https://pubmed.ncbi.nlm.nih.gov/31092190
حقوق: OPEN
رقم الأكسشن: edsair.doi.dedup.....e612edc8842af63a4c0ed5e05856aeb4
قاعدة البيانات: OpenAIRE
الوصف
تدمد:11292377