Treatment outcomes and related clinical characteristics in patients with burning mouth syndrome
| العنوان: | Treatment outcomes and related clinical characteristics in patients with burning mouth syndrome |
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| المؤلفون: | Moon-Jong Kim, Ji Hoon Kim, Hong-Seop Kho |
| المصدر: | Oral Diseases. 27:1507-1518 |
| بيانات النشر: | Wiley, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | medicine.medical_specialty, Gabapentin, Treatment outcome, Burning Mouth Syndrome, Clonazepam, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, medicine, Humans, In patient, General Dentistry, Depression (differential diagnoses), Retrospective Studies, business.industry, Retrospective cohort study, 030206 dentistry, Burning mouth syndrome, stomatognathic diseases, Treatment Outcome, Otorhinolaryngology, 030220 oncology & carcinogenesis, Nortriptyline, medicine.symptom, business, medicine.drug |
| الوصف: | Objectives To evaluate the treatment outcomes of medication therapies in patients with burning mouth syndrome (BMS) and to identify the clinical characteristics that may affect the efficacy of prescribed medications. Methods This is a retrospective study of 769 patients with oral burning sensations. Of these patients, 420 patients diagnosed as the primary BMS received an "Initial Approach" that involved a detailed explanation about its etiopathophysiology, self-care instruction, and use of an oral lubricant. Neuropathic medications were prescribed for 277 patients who did not respond to the initial approach. Clinical characteristics, prescribed medications, and changes in intensity of oral symptoms were reviewed. Results Clonazepam was administered as the first-line medication. Alpha-lipoic acid (ALA), gabapentin, and nortriptyline were commonly administered in combination with clonazepam. More than two-thirds of the patients reported a marked improvement in oral symptoms after treatments with combination of neuropathic medications and ALA. The efficacies of the initial approach and clonazepam had significant positive associations with the initial intensity of oral symptoms and significant negative associations with depression. Conclusions Clonazepam therapy in combination with appropriate medications was effective for managing patients with BMS. The initial intensity of oral symptoms and psychological status were significantly associated with treatment outcomes. |
| تدمد: | 1601-0825 1354-523X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e63db3826f2f42a3e8b32a887aa1e3d5 https://doi.org/10.1111/odi.13693 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e63db3826f2f42a3e8b32a887aa1e3d5 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16010825 1354523X |
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