Radiation Therapy with Concurrent Chemotherapy for Locally Advanced Cervical Carcinoma: Outcome Analysis with Emphasis on the Impact of Treatment Duration on Outcome
| العنوان: | Radiation Therapy with Concurrent Chemotherapy for Locally Advanced Cervical Carcinoma: Outcome Analysis with Emphasis on the Impact of Treatment Duration on Outcome |
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| المؤلفون: | Enrique Hernandez, B Micaily, J. Stuart Ferriss, Juan Diaz, Daohai Yu |
| المصدر: | Obstetrics and Gynecology International Obstetrics and Gynecology International, Vol 2014 (2014) |
| بيانات النشر: | Hindawi Limited, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Cisplatin, Cervical cancer, medicine.medical_specialty, Article Subject, business.industry, Treatment duration, medicine.medical_treatment, Brachytherapy, Urology, Locally advanced, Obstetrics and Gynecology, medicine.disease, lcsh:Gynecology and obstetrics, Carboplatin, Surgery, Radiation therapy, chemistry.chemical_compound, chemistry, Toxicity, Medicine, business, lcsh:RG1-991, Research Article, medicine.drug |
| الوصف: | Objective. To assess the effectiveness and toxicity of carboplatin concurrent with pelvic external beam radiation and low-dose rate brachytherapy and to assess the impact that adherence to the treatment plan has on outcomes.Methods. Retrospective chart review of 56 patients treated from January 2001 to December 2010.Results. Median follow-up was 68 months. Optimal dose of radiation (ORT) was defined as a minimal cervical dose exceeding 70 Gy, point A dose of 80–90 Gy, and duration not exceeding 56 days. Only 50% received ORT. In multivariable analyses we only found ORT to be statistically significant predictor for progression-free survival (PFS) and overall survival (OS) (HR [95% CI] for non-ORT vs. ORT: 2.4 [1.2, 5.1],P=0.014for PFS and 2.2 [1.1, 4.6],P=0.035for OS). The 5-year PFS in patients who received ORT was better than that in patients who received non-ORT, 56% vs. 22% (95% CI: [36%, 72%] vs. [9%, 39%]). Patients who received ORT had a better 5-year OS as well (59% vs. 33%; 95% CI: [38%, 75%] vs. [16%, 51%]).Conclusion. Patients with locally advanced cervical cancer treated with weakly carboplatin or cisplatin, teletherapy, and low dose-dose rate brachytherapy have poorer outcomes when treatment duration is prolonged. |
| وصف الملف: | text/xhtml |
| تدمد: | 1687-9597 1687-9589 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e650d7d2de8a74e4efeeb7ba98b52767 https://doi.org/10.1155/2014/214351 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e650d7d2de8a74e4efeeb7ba98b52767 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 16879597 16879589 |
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