Cutting Edge: The Y Chromosome Controls the Age-Dependent Experimental Allergic Encephalomyelitis Sexual Dimorphism in SJL/J Mice
| العنوان: | Cutting Edge: The Y Chromosome Controls the Age-Dependent Experimental Allergic Encephalomyelitis Sexual Dimorphism in SJL/J Mice |
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| المؤلفون: | Elizabeth P. Blankenhorn, Karen M. Spach, Melissa Blake, Janice Y. Bunn, Ben McElvany, Cory Teuscher, Rajkumar Noubade |
| المصدر: | The Journal of Immunology. 182:1789-1793 |
| بيانات النشر: | The American Association of Immunologists, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Male, Encephalomyelitis, Autoimmune, Experimental, Proteolipid protein 1, Encephalomyelitis, Immunology, chemical and pharmacologic phenomena, Biology, Y chromosome, Article, Mice, immune system diseases, Polymorphism (computer science), Y Chromosome, medicine, Demyelinating disease, Animals, Immunology and Allergy, Genetic Predisposition to Disease, Sex Characteristics, Multiple sclerosis, Age Factors, hemic and immune systems, medicine.disease, nervous system diseases, Sexual dimorphism, Female, Seasons, Sex characteristics |
| الوصف: | Multiple sclerosis is a sexually dimorphic, demyelinating disease of the CNS, and experimental allergic encephalomyelitis (EAE) is its principal autoimmune model. Young male SJL/J mice are relatively resistant to EAE whereas older males and SJL/J females of any age are susceptible. By comparing a wide age range of proteolipid protein peptide 139–151 immunized mice, we found that female disease severity remains constant with age. In contrast, EAE disease severity increases with age in SJL/J males, with young males having significantly less severe disease and older males having significantly more disease than equivalently aged females. To determine whether the Y chromosome contributes to this sexual dimorphism, EAE was induced in consomic SJL/J mice carrying a B10.S Y chromosome (SJL.YB10.S). EAE was significantly more severe in young male SJL.YB10.S mice compared with young male SJL/J mice. These studies show that a Y chromosome-linked polymorphism controls the age-dependent EAE sexual dimorphism observed in SJL/J mice. |
| تدمد: | 1550-6606 0022-1767 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e652dd5b5d7fca603983d2e11463dc2a https://doi.org/10.4049/jimmunol.0803200 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e652dd5b5d7fca603983d2e11463dc2a |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15506606 00221767 |
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