Biocompatibility of Hydroxylated Metabolites of BISGMA and BFDGE
| العنوان: | Biocompatibility of Hydroxylated Metabolites of BISGMA and BFDGE |
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| المؤلفون: | Steve Burmaster, W.V. Welshons, B.M. Judy, Elisabet L. Kostoryz, J.D. Eick, Alan G. Glaros, David M. Yourtee |
| المصدر: | Journal of Dental Research. 82:367-371 |
| بيانات النشر: | SAGE Publications, 2003. |
| سنة النشر: | 2003 |
| مصطلحات موضوعية: | endocrine system, Bisphenol A, Metabolite, Biocompatible Materials, Ether, 010501 environmental sciences, Hydroxylation, 01 natural sciences, Ames test, Dental Materials, Mice, 03 medical and health sciences, chemistry.chemical_compound, L Cells, 0302 clinical medicine, Materials Testing, Toxicity Tests, Animals, Humans, Organic chemistry, Bisphenol A-Glycidyl Methacrylate, Estrogens, Non-Steroidal, Benzhydryl Compounds, Cytotoxicity, General Dentistry, Bisphenol A diglycidyl ether, Cells, Cultured, 0105 earth and related environmental sciences, Mutagenicity Tests, 030206 dentistry, chemistry, Inactivation, Metabolic, Microsomes, Liver, Microsome, Epoxy Compounds |
| الوصف: | Unpolymerized dental monomers can leach out into the oral biophase and are bioavailable for metabolism. We hypothesize that metabolites would be less toxic than parent monomers. We first identified the formation of metabolites from bisphenol F diglycidyl ether (BFDGE) and Bisphenol A glycidyl methacrylate (BISGMA) after their exposure to liver S9 fractions. Then, the metabolites and parent compounds were subjected to in vitro cytotoxicity, mutagenicity, and estrogenicity studies. Bisphenol A bis(2,3-dihydroxypropyl) ether and bisphenol F bis(2,3-dihydroxypropyl) ether were the hydroxylated metabolites of BISGMA and BFDGE, respectively. Cytotoxicity against L929 cells showed that the metabolites were significantly ( p < 0.05) less cytotoxic than the parent monomers. Only BFDGE was mutagenic in the Ames assay with strain TA100 of Salmonella typhimurium. Parent and metabolite compounds did not stimulate estrogen-dependent MCF-7 cell proliferation above solvent controls. These results indicated that the hydroxylated metabolites were non-mutagenic, non-estrogenic, and less cytotoxic than their parent monomers. |
| تدمد: | 1544-0591 0022-0345 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e657709f91624d657c750bfdca36234b https://doi.org/10.1177/154405910308200508 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e657709f91624d657c750bfdca36234b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15440591 00220345 |
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