A prospective international multi-center study on safety and efficacy of deep brain stimulation for resistant obsessive-compulsive disorder
| العنوان: | A prospective international multi-center study on safety and efficacy of deep brain stimulation for resistant obsessive-compulsive disorder |
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| المؤلفون: | Renana Eitan, Bart Nuttin, José M. Menchón, Eva Real, Tim Brelje, Volker M. Tronnier, Georg Löffelholz, Giuseppe Messina, Zvi Israel, Angelo Franzini, Andreas Kordon, Laurean Matthijs, Mercedes Prieto, Els Brunfaut, Gastón Schechtmann, Lennart Stieglitz, Diana Radu-Djurfeldt, Antonio Higueras, Bartosz Zurowski, Long-Long Chen, Claudio Pollo, Michael Schuepbach, Chris Bervoets, Simon Raymakers, Majed Katati, Mariena Hurtado, Cinto Segalàs, Frans Gielen, Marco Alberto Aparicio, Orsola Gambini, Hagai Bergman, Loes Gabriëls, José Guerrero, Laura Luyten, Thomas C. Brionne, Sebastian Walther, Aurélie Conseil, Gerard Plans, Rebecca Ranieri, Pino Alonso |
| المصدر: | Dipòsit Digital de la UB Universidad de Barcelona Menchón, José M; Real, Eva; Alonso, Pino; Aparicio, Marco Alberto; Segalas, Cinto; Plans, Gerard; Luyten, Laura; Brunfaut, Els; Matthijs, Laurean; Raymakers, Simon; Bervoets, Chris; Higueras, Antonio; Katati, Majed; Guerrero, José; Hurtado, Mariena; Prieto, Mercedes; Stieglitz, Lennart H; Löffelholz, Georg; Walther, Sebastian; Pollo, Claudio; ... (2021). A prospective international multi-center study on safety and efficacy of deep brain stimulation for resistant obsessive-compulsive disorder. Molecular psychiatry, 26(4), pp. 1234-1247. Nature Publishing Group 10.1038/s41380-019-0562-6 <http://dx.doi.org/10.1038/s41380-019-0562-6> Molecular Psychiatry |
| بيانات النشر: | Nature Publishing Group, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Seguretat dels pacients, medicine.medical_specialty, Obsessive-Compulsive Disorder, Deep brain stimulation, Exacerbation, medicine.medical_treatment, Deep Brain Stimulation, Population, Estimulació del cervell, Stimulation, 610 Medicine & health, Anxiety, Article, Cellular and Molecular Neuroscience, Internal Capsule, Internal medicine, medicine, Obsessive-compulsive disorder, Humans, Prospective Studies, Adverse effect, education, Molecular Biology, Patients safety, education.field_of_study, business.industry, Depression, Incidence (epidemiology), Neurosi obsessiva, Psychiatry and Mental health, Treatment Outcome, Brain stimulation, Etiology, medicine.symptom, business, Psychiatric disorders |
| الوصف: | Deep brain stimulation (DBS) has been proposed for severe, chronic, treatment-refractory obsessive-compulsive disorder (OCD) patients. Although serious adverse events can occur, only a few studies report on the safety profile of DBS for psychiatric disorders. In a prospective, open-label, interventional multi-center study, we examined the safety and efficacy of electrical stimulation in 30 patients with DBS electrodes bilaterally implanted in the anterior limb of the internal capsule. Safety, efficacy, and functionality assessments were performed at 3, 6, and 12 months post implant. An independent Clinical Events Committee classified and coded all adverse events (AEs) according to EN ISO14155:2011. All patients experienced AEs (195 in total), with the majority of these being mild (52% of all AEs) or moderate (37%). Median time to resolution was 22 days for all AEs and the etiology with the highest AE incidence was 'programming/stimulation' (in 26 patients), followed by 'New illness, injury, condition' (13 patients) and 'pre-existing condition, worsening or exacerbation' (11 patients). Sixteen patients reported a total of 36 serious AEs (eight of them in one single patient), mainly transient anxiety and affective symptoms worsening (20 SAEs). Regarding efficacy measures, Y-BOCS reduction was 42% at 12 months and the responder rate was 60%. Improvements in GAF, CGI, and EuroQol-5D index scores were also observed. In sum, although some severe AEs occurred, most AEs were mild or moderate, transient and related to programming/stimulation and tended to resolve by adjustment of stimulation. In a severely treatment-resistant population, this open-label study supports that the potential benefits outweigh the potential risks of DBS. ispartof: Molecular Psychiatry vol:26 issue:4 pages:1-14 ispartof: location:England status: Published online |
| وصف الملف: | application/pdf; Print-Electronic |
| اللغة: | English |
| DOI: | 10.7892/boris.134406 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e67a45e4a2c929810bd26bc926016a68 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e67a45e4a2c929810bd26bc926016a68 |
| قاعدة البيانات: | OpenAIRE |
| DOI: | 10.7892/boris.134406 |
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