Aldehyde dehydrogenase 1 (ALDH1) isoform expression and potential clinical implications in hepatocellular carcinoma
| العنوان: | Aldehyde dehydrogenase 1 (ALDH1) isoform expression and potential clinical implications in hepatocellular carcinoma |
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| المؤلفون: | Si Cong Lu, Min Hao Peng, Long Yu, Yu Liang, Kai Yin Xiao, Stephen J. O'Brien, Zhengtao Liu, Wei Qin, Tao Peng, Xiang‑Kun Wang, Zhiwei Chen, Ke Tuan Huang, Xiao Guang Liu, Hao Su, Jian Lu Huang, Cheng Kun Yang, Guang Zhi Zhu, Ting Dong Yu, Zhen Liu, Cheryl Ann Winkle, Chuang Ye Han, Xi‑Wen Liao |
| المصدر: | PLoS ONE, Vol 12, Iss 8, p e0182208 (2017) PLoS ONE |
| بيانات النشر: | Public Library of Science (PLoS), 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | 0301 basic medicine, Datasets as Topic, Gene Expression, lcsh:Medicine, Aldehyde dehydrogenase, Bioinformatics, medicine.disease_cause, Mathematical and Statistical Techniques, 0302 clinical medicine, Recurrence, Animal Cells, Gene expression, Medicine and Health Sciences, lcsh:Science, Regulation of gene expression, Multidisciplinary, biology, Organic Compounds, Liver Diseases, Stem Cells, Liver Neoplasms, Hepatitis B, Prognosis, Gene Expression Regulation, Neoplastic, Isoenzymes, Chemistry, Oncology, Research Design, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Physical Sciences, Cellular Types, Statistics (Mathematics), Research Article, Hepatitis B virus, Carcinoma, Hepatocellular, Clinical Research Design, Gastroenterology and Hepatology, Acetaldehyde, Research and Analysis Methods, Carcinomas, Aldehyde Dehydrogenase 1 Family, Disease-Free Survival, 03 medical and health sciences, Diagnostic Medicine, Gastrointestinal Tumors, Biomarkers, Tumor, Genetics, Cancer Detection and Diagnosis, medicine, Carcinoma, Humans, RNA, Messenger, Statistical Methods, Aldehydes, Ethanol, Organic Chemistry, lcsh:R, Chemical Compounds, Retinal Dehydrogenase, Cancers and Neoplasms, Biology and Life Sciences, Cancer, Hepatocellular Carcinoma, Cell Biology, medicine.disease, Survival Analysis, digestive system diseases, ALDH1A1, Logistic Models, 030104 developmental biology, Alcohols, biology.protein, Cancer research, lcsh:Q, Software, Mathematics |
| الوصف: | Hepatocellular carcinoma (HCC) is one of the most prevalent and life-threatening malignancies worldwide. There are few diagnostic and prognostic biomarkers and druggable targets for HCC. Aldehyde dehydrogenase 1 (ALDH1) is a marker of stem cells in a variety of cancers, but the mRNA levels and prognostic value of ALDH1 isoforms in HCC patients remain unknown. In the present study, gene ontology annotation of the ALDH1 family was performed using the Database for Annotation, Visualization and Integrated Discovery (DAVID), and the gene pathway analsis was performed using GeneMANIA software. The initial prognostic value of ALDH1 expression in 360 HCC patients was assessed using the OncoLnc database. The expression levels of ALDH1 isoforms in normal liver tissues and clinical specimens of cancer vs. normal control datasets were determined using the GTEx and Oncomine databases, respectively. We then analyzed the prognostic value of ALDH1 expression in 212 hepatitis B virus (HBV)–related HCC patients using the GEO database. We found that the ALDH1 isoform showed high aldehyde dehydrogenase activity. The ALDH1A1, ALDH1B1, and ALDH1L1 genes encoded for the ALDH1 enzyme. High ALDH1B1 expression had protective qualities in HCC patients. Moreover, HBV–related HCC patients who showed high ALDH1L1 gene expression had a better clinical outcomes. In addition, high ALDH1A1 expression was associated with a 57–month recurrence–free survival in HBV-related HCC patients. High ALDH1B1 expression was protective for HCCs with multiple nodules and high serum alpha–fetoprotein (AFP) level. Furthermore, high serum AFP levels contributed to lower ALDH1L1. ALDH1A1, ALDH1B1, and ALDH1L1, all of which were considered promising diagnostic and prognostic markers as well as potential drug targets. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e68612431466e2d820b944151239c2f3 https://doi.org/10.1371/journal.pone.0182208 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e68612431466e2d820b944151239c2f3 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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