Chemotherapy for mobilisation of Ph-negative progenitor cells from patients with CML: impact of different mobilisation regimens
| العنوان: | Chemotherapy for mobilisation of Ph-negative progenitor cells from patients with CML: impact of different mobilisation regimens |
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| المؤلفون: | A. Franke, Andreas Schwarzer, M. Herold, F. Fiedler, U von Grünhagen, J Doepper, G Dölken, Thoralf Lange, W Schultze, Cornelia Winkelmann, Hoffmann Fa, Erika Kettner, Elvira Edel, R. Uhle, Dietger Niederwieser, Sabine Leiblein, E Schwalbe, R. Krahl, Wolfram Pönisch, Rita Subert, Klaus Dachselt, Rita Pasold, Michael W. Deininger, W. Helbig, J. Steglich, M. Freund, P. Richter |
| المصدر: | Bone Marrow Transplantation. 27:1125-1132 |
| بيانات النشر: | Springer Science and Business Media LLC, 2001. |
| سنة النشر: | 2001 |
| مصطلحات موضوعية: | Adult, Male, Oncology, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Leukemia, Myelogenous, Chronic, BCR-ABL Positive, hemic and lymphatic diseases, Internal medicine, Antineoplastic Combined Chemotherapy Protocols, Granulocyte Colony-Stimulating Factor, Ph Negative, Humans, Medicine, Philadelphia Chromosome, Leukapheresis, Progenitor cell, Cyclophosphamide, Transplantation, Chemotherapy, business.industry, Graft Survival, Cytarabine, Interferon-alpha, Hematology, Middle Aged, Hematopoietic Stem Cell Mobilization, Stem cell mobilisation, Female, Idarubicin, business |
| الوصف: | Mobilised peripheral blood stem cells are widely used for autografting in patients with chronic myeloid leukaemia (CML) and it is generally thought that a high proportion of Ph-negative progenitor cells in the graft is desirable. We report here the results of 91 stem cell mobilisations performed with various chemotherapy regimens followed by G-CSF. We show that mobilisation of Ph-negative cells is possible after diagnosis as well as in advanced stages of the disease. The yield of Ph-negative cells is highly dependent on the chemotherapy regimen: while the combination of idarubicin and cytarabin for 3-5 days (IC3-5) mobilised Ph-negative cells in most patients, high-dose cyclophosphamide was ineffective. Mobilisation of Ph-negative progenitor cells after IC3 was at least as effective as after IC5; however, less apheresis sessions were required, and toxicity was much reduced after IC3. Compared to historical controls, IC was equally effective as the widely used ICE/miniICE (idarubicin, cytarabin, etoposide) protocol. No correlation was found between graft quality and the cytogenetic response to subsequent treatment with interferon-alpha. We conclude that IC3 is an effective and well-tolerated regimen for mobilising Ph-negative cells that compares well with more aggressive approaches such as IC5 and ICE/miniICE. |
| تدمد: | 1476-5365 0268-3369 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6b63c7b19d06e00af6d4092a7be4ff4 https://doi.org/10.1038/sj.bmt.1703057 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e6b63c7b19d06e00af6d4092a7be4ff4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14765365 02683369 |
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