A novel clinicopathological analysis of early stage ovarian Sertoli-Leydig cell tumors at a single institution
| العنوان: | A novel clinicopathological analysis of early stage ovarian Sertoli-Leydig cell tumors at a single institution |
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| المؤلفون: | Kyung Jin Eoh, Young Tae Kim, Eun Ji Nam, Jung Yun Lee, Sunghoon Kim, Sang Wun Kim, Jee Whan Kim, Hye Min Kim, Seon Mi Nam |
| المصدر: | Obstetrics & Gynecology Science |
| بيانات النشر: | Korean Society of Obstetrics and Gynecology, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Oncology, medicine.medical_specialty, Histology, medicine.medical_treatment, Bleomycin, Ovarian neoplasms, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Internal medicine, medicine, Carcinoma, Stage (cooking), Lymph node, Etoposide, 030219 obstetrics & reproductive medicine, Hysterectomy, Sertoli-Leydig cell tumor, business.industry, Obstetrics and Gynecology, Gynecologic Oncology, medicine.disease, Surgery, Regimen, Dissection, medicine.anatomical_structure, chemistry, 030220 oncology & carcinogenesis, Original Article, Drug therapy, business, medicine.drug |
| الوصف: | Objective To evaluate the clinical and pathologic characteristics of patients who were diagnosed with ovarian Sertoli-Leydig cell tumors (SLCTs) in a single institution. Methods The medical records of 11 patients who were pathologically diagnosed with SLCTs beginning in 1995 in a single institute was reviewed. Results The median patient age was 31 years (range, 16 to 70 years). Patient International Federation of Gynecology and Obstetrics stages were IA, IC, and IIB in 3 (27.3%), 6 (54.5%), and 2 (18.2%) patients, respectively. Six patients (54.5%) had grade 3 tumors, 3 patients (27.3%) had grade 2 tumors, and 1 patient (9.1%) had a grade 1 tumor. Four patients without children underwent fertility-sparing surgery, and 7 patients had full staging surgery, including a hysterectomy and bilateral salpingo-oophorectomy, with a laparoscopic approach used in 3. Eight patients underwent pelvic lymph node dissection, and 8 patients were administered adjuvant chemotherapy consisting of bleomycin, etoposide, and cisplatin in 6 cases, a modified bleomycin, etoposide, and cisplatin regimen in 1 case, and a combined paclitaxel and cisplatin regimen in 1 case. Two patients died of disease and were re-diagnosed with Sertoli form endometrioid carcinoma. The other patients remain alive without recurrence at the time of reporting. Conclusion Our findings suggest that regardless of tumor stage or grade, ovarian SLCT patients have a good prognosis. Close observation and unilateral salpingo-oophorectomy would be beneficial for women who still wish to have children, while hysterectomy and bilateral salpingo-oophorectomy with adjuvant chemotherapy would be the optimal treatment in other cases. Furthermore, meticulous pathologic diagnosis is needed to develop a precise treatment strategy. |
| تدمد: | 2287-8580 2287-8572 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6d32dbb05cf55aec158fcfdae077d5f https://doi.org/10.5468/ogs.2017.60.1.39 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e6d32dbb05cf55aec158fcfdae077d5f |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 22878580 22878572 |
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