LncRNA-CASC7 inhibits the proliferation and migration of colon cancer by negatively regulating the PI3K/Akt signaling pathway
| العنوان: | LncRNA-CASC7 inhibits the proliferation and migration of colon cancer by negatively regulating the PI3K/Akt signaling pathway |
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| المؤلفون: | Bo, Hao, Hexin, Wen, Yingying, Sun, Zhenghong, Le, Zongbing, Zhang, Mulin, Liu, Ting, Hu |
| المصدر: | J Gastrointest Oncol |
| بيانات النشر: | AME Publishing Company, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Oncology, Gastroenterology, Original Article |
| الوصف: | BACKGROUND: This study aims to investigate the effect of LncRNA-CASC7 (cancer susceptibility candidate 7) on the proliferation and migration of colon cancer cells and its possible mechanism. METHODS: In this study, quantitative real-time polymerase chain reaction (qRT-PCR) was employed for the detection of lncRNA-CASC7 expression in 54 colon cancer tissues and 5 colon cancer cell lines. This study aimed to evaluate the significant correlation between the lncRNA-CASC7 expression, the clinical features, and the survival rate of patients. LncRNA-CASC7 was overexpressed by lipofectin transfection. Cell proliferation was detected by the methyl thiazolyl tetrazolium (MTT) assay. Transwell assay was conducted to examine cell migration and invasion. The target gene was verified by dual fluorescein. The expression of proliferation and invasion-related proteins was detected via western blotting (WB). RESULTS: The LncRNA-CASC7 expression in colon cancer was considerably decreased than in nearby healthy tissues (P |
| تدمد: | 2219-679X 2078-6891 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6df7c479d20dace26629eb585b3e275 https://doi.org/10.21037/jgo-21-643 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e6df7c479d20dace26629eb585b3e275 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 2219679X 20786891 |
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