Suppression of Dengue Virus Replication in Vitro by Rimantadine Hydrochloride *
| العنوان: | Suppression of Dengue Virus Replication in Vitro by Rimantadine Hydrochloride * |
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| المؤلفون: | Joe L. Elm, Wayne C. Koff, Scott B. Halstead |
| المصدر: | The American Journal of Tropical Medicine and Hygiene. 30:184-189 |
| بيانات النشر: | American Society of Tropical Medicine and Hygiene, 1981. |
| سنة النشر: | 1981 |
| مصطلحات موضوعية: | Drug, Time Factors, Rimantadine, viruses, media_common.quotation_subject, Microgram, Adamantane, Dengue virus, Biology, Virus Replication, medicine.disease_cause, Microbiology, Dengue, Tissue culture, Virology, Leukocytes, medicine, Rimantadine Hydrochloride, Animals, Humans, media_common, Dengue Virus, Macaca mulatta, In vitro, Infectious Diseases, Cell culture, Parasitology, medicine.drug |
| الوصف: | The effects of rimantadine on dengue virus replication were examined in a variety of tissue culture systems. The growth of dengue virus type 2 in human peripheral blood leukocytes (PBL) was completely suppressed when rimantadine was included in the culture medium at a concentration of 25 microgram/ml. Similarly, rimantadine caused a significant inhibition of dengue virus replicaton in cultures of rhesus monkey PBL. Addition of drug into virus-infected LLC-MK2 cell cultures caused a decrease in the production of all four types of dengue virus. Maximal inhibition of dengue virus replication by rimantadine was observed when the drug was added immediately following the viral adsorption period. Rimantadine did not induce may cytopathic effects on either LLC-MK2 cells or PBL at concentrations less than 75 microgram/ml. These findings demonstrate that rimantadine is an effective inhibitor of dengue virus replication in vitro, and indicate a need for further examination of the efficacy of rimantadine against severe dengue virus disease. |
| تدمد: | 1476-1645 0002-9637 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6f2f14c808acf4feb5c5e6e3212d7b4 https://doi.org/10.4269/ajtmh.1981.30.184 |
| رقم الأكسشن: | edsair.doi.dedup.....e6f2f14c808acf4feb5c5e6e3212d7b4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14761645 00029637 |
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