IL-10-producing B cells regulate Th1/Th17-cell immune responses inPneumocystispneumonia
| العنوان: | IL-10-producing B cells regulate Th1/Th17-cell immune responses inPneumocystispneumonia |
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| المؤلفون: | Chao Zhang, Dong Wang, Heng-Mo Rong, Zhaohui Tong, Yang Hu, Ting Li, Huan-Zhong Shi, Kan Zhai |
| المصدر: | American Journal of Physiology-Lung Cellular and Molecular Physiology. 316:L291-L301 |
| بيانات النشر: | American Physiological Society, 2019. |
| سنة النشر: | 2019 |
| مصطلحات موضوعية: | Adult, Male, 0301 basic medicine, Pulmonary and Respiratory Medicine, Physiology, Interleukin-1beta, Cell, Pneumocystis pneumonia, Mice, 03 medical and health sciences, Th2 Cells, 0302 clinical medicine, Immune system, Physiology (medical), medicine, Animals, Humans, Th1 th17, Antibodies, Fungal, Mice, Knockout, B-Lymphocytes, Pneumocystis, business.industry, Pneumonia, Pneumocystis, Cell Biology, Th1 Cells, Immunosuppressed Hosts, medicine.disease, Interleukin-10, Interleukin 10, Pneumonia, 030104 developmental biology, medicine.anatomical_structure, Immunoglobulin M, 030228 respiratory system, Immunoglobulin G, Opportunistic infectious disease, Immunology, Female, business, B-Cell Activation Factor Receptor |
| الوصف: | Pneumocystis pneumonia (PCP) is a common opportunistic infectious disease that is prevalent in immunosuppressed hosts. Accumulating evidence shows that B cells play an important role in infectious diseases. In the present study, the immune regulatory role of mature B cells in host defense to Pneumocystis was evaluated. Pneumocystis infection resulted in a decrease in B cells in patients and mice, and the Pneumocystis burden in B cell-deficient mice also progressively increased from weeks 1 to 7 after infection. The clearance of Pneumocystis was delayed in B cell-activating factor receptor (BAFF-R)-deficient mice (BAFF-R−/−mice), which had few B cells and Pneumocystis-specific IgG and IgM antibodies, compared with clearance in wild-type (WT) mice. There were fewer effector CD4+T cells and higher percentages of T helper (Th)1/Th17 cells in BAFF-R−/−mice than in WT mice. Adoptive transfer of naive B cells, mRNA sequencing, and IL-1β neutralization experiments indicated that IL-1β is a likely determinant of the IL-10-producing B cell-mediated suppression of Th1/Th17-cell immune responses in BAFF-R−/−PCP mice. Our data indicated that B cells play a vital role in the regulation of Th cells in response to Pneumocystis infection. |
| تدمد: | 1522-1504 1040-0605 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e73e8df140492297a9a8b3351e91ce9c https://doi.org/10.1152/ajplung.00210.2018 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e73e8df140492297a9a8b3351e91ce9c |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15221504 10400605 |
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