Effects of Lecithinized Superoxide Dismutase on Traumatic Brain Injury in Rats
| العنوان: | Effects of Lecithinized Superoxide Dismutase on Traumatic Brain Injury in Rats |
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| المؤلفون: | Masamitsu Kawauchi, Shoji Asari, Y. Noguchi, Masatoshi Yunoki, Naoya Ukita, Takashi Ohmoto, Norio Ogawa, Yasuhiro Ono, Masato Asanuma, Shinsaku Nishio |
| المصدر: | Journal of Neurotrauma. 14:739-746 |
| بيانات النشر: | Mary Ann Liebert Inc, 1997. |
| سنة النشر: | 1997 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Pathology, Traumatic brain injury, Cerebral edema, Rats, Sprague-Dawley, Lesion, Cerebral contusion, Superoxide dismutase, chemistry.chemical_compound, Body Water, Internal medicine, medicine, Extracellular, Animals, RNA, Messenger, Cerebral Cortex, chemistry.chemical_classification, Reactive oxygen species, biology, Superoxide Dismutase, Superoxide, business.industry, medicine.disease, Rats, Endocrinology, chemistry, Brain Injuries, Phosphatidylcholines, biology.protein, Neurology (clinical), medicine.symptom, business |
| الوصف: | Only small amounts of superoxide dismutase (SOD) are present in the extracellular space to scavenge excess amounts of superoxide anions (02-) released after traumatic brain injury (TBI). Experiments were performed in rats with cerebral contusion produced by weight-drop technique. We investigated the effects of exogenous lecithinized SOD (PC-SOD) on accumulation of 02- produced in our model, by measuring the level of SOD activity (using the NBT-reducing method) and the expression of copper, zinc-SOD (Cu, Zn-SOD) mRNA (by Northern blot analysis). As determined by tissue-specific gravity, administration of PC-SOD reduced brain edema in the periphery of the lesion 6 h after contusion. SOD activity increased in the peripheral region at 30 min after contusion, but returned to normal levels at 6 h after TBI. Administration of PC-SOD increased SOD activity up to 6 h after TBI. The expression of Cu, Zn-SOD mRNA increased in the core region, peripheral portion, and contralateral hemisphere up to 6 h after TBI, then was suppressed in all three regions by PC-SOD. Our results confirm the important role of 02- in the development of brain edema after TBI and indicate that PC-SOD diminishes brain edema through a protective effect against 02-. |
| تدمد: | 1557-9042 0897-7151 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e74cff62ac275a3f00a19c385a6f9ee9 https://doi.org/10.1089/neu.1997.14.739 |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e74cff62ac275a3f00a19c385a6f9ee9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15579042 08977151 |
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