The association between the number of symptoms and the severity of Post-COVID-Fatigue after SARS-CoV-2 infection treated in an outpatient setting
| العنوان: | The association between the number of symptoms and the severity of Post-COVID-Fatigue after SARS-CoV-2 infection treated in an outpatient setting |
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| المؤلفون: | Lena Schmidbauer, Inge Kirchberger, Yvonne Goßlau, Tobias D. Warm, Alexander Hyhlik-Dürr, Jakob Linseisen, Christa Meisinger |
| المصدر: | Journal of Neurology. |
| بيانات النشر: | Springer Science and Business Media LLC, 2023. |
| سنة النشر: | 2023 |
| مصطلحات موضوعية: | Neurology, ddc:610, Neurology (clinical) |
| الوصف: | Background Post-COVID-Fatigue (PCF) is one of the most reported symptoms following SARS-CoV-2 infection. Currently, research on persistent symptoms focuses mainly on severe infections, while outpatients are rarely included in observations. Objective To investigate whether the severity of PCF is related to the number of acute and persistent symptoms due to mild-to-moderate COVID-19 and to compare the most common symptoms during acute infection with the persistent symptoms in PCF patients. Methods A total of 425 participants were examined after COVID-19 treated as an outpatient (median 249 days [IQR: 135; 322] after acute disease) at the site of University Hospital Augsburg, Germany. The Fatigue Assessment Scale (FAS) was used to quantify the severity of PCF. The number of symptoms (maximum 41) during acute infection and persistent symptoms (during the last 14 days before examination) were added up to sum scores. Multivariable linear regression models were used to show the association between the number of symptoms and PCF. Results Of the 425 participants, 37% (n = 157) developed PCF; most were women (70%). The median number of symptoms was significantly higher in the PCF group than in the non-PCF group at both time points. In multivariable linear regression models, both sum scores were associated with PCF (acute symptoms: β-estimate per additional symptom [95%-CI]: 0.48 [0.39; 0.57], p p Conclusion Each additional symptom that occurs in COVID-19 increases the likelihood of suffering a higher severity of PCF. Further research is needed to identify the aetiology of PCF. Trial registration: Nr. NCT04615026. Date of registration: November 4, 2020. |
| وصف الملف: | application/pdf |
| تدمد: | 1432-1459 0340-5354 0461-5026 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e772ea2ccffc76c4b41f2cfd0c0e015e https://doi.org/10.1007/s00415-023-11752-9 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e772ea2ccffc76c4b41f2cfd0c0e015e |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 14321459 03405354 04615026 |
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