Association Between Clinical Measures and Florbetapir F18 PET Neuroimaging in Mild or Moderate Alzheimer’s Disease Dementia
| العنوان: | Association Between Clinical Measures and Florbetapir F18 PET Neuroimaging in Mild or Moderate Alzheimer’s Disease Dementia |
|---|---|
| المؤلفون: | Mitchell Quinlivan, Michael M. Witte, David Henley, Peng Yu, Paula T. Trzepacz, Michael Case, Karen Sundell, Helen Hochstetler |
| المصدر: | The Journal of Neuropsychiatry and Clinical Neurosciences. 26:214-220 |
| بيانات النشر: | American Psychiatric Association Publishing, 2014. |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Male, medicine.medical_specialty, Pediatrics, Cross-sectional study, Neuropathology, Disease, Neuroimaging, Alzheimer Disease, medicine, Humans, Dementia, Psychiatry, Aged, Retrospective Studies, Aged, 80 and over, Psychiatric Status Rating Scales, Analysis of Variance, Aniline Compounds, medicine.diagnostic_test, business.industry, Brain, Retrospective cohort study, Middle Aged, medicine.disease, Clinical trial, Psychiatry and Mental health, Cross-Sectional Studies, Positron emission tomography, Positron-Emission Tomography, Ethylene Glycols, Female, Neurology (clinical), business |
| الوصف: | Clinical diagnosis of Alzheimer's disease (AD) is challenging, with 20% or more of patients misdiagnosed, even by expert clinicians. The authors conducted a retrospective, cross-sectional analysis comparing baseline neuropsychiatric and other clinical characteristics in 199 expert-diagnosed mild and moderate AD dementia patients participating in industry-sponsored clinical trials of an investigational therapy, where 18% lacked florbetapir positron emission tomography (PET) evidence of AD neuropathology. Significant differences were found only for cognition and ApoE ε4 status, but the large degree of score overlap would preclude using these measures to predict AD misdiagnosis. This study highlights the value of amyloid PET when evaluating patients with seemingly typical AD. |
| تدمد: | 1545-7222 0895-0172 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7b4f6580bf892795d28bdf71b659e28 https://doi.org/10.1176/appi.neuropsych.12120402 |
| رقم الأكسشن: | edsair.doi.dedup.....e7b4f6580bf892795d28bdf71b659e28 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15457222 08950172 |
|---|