Comparative study of the effects of osteoprotegerin and testosterone on bone quality in male orchidectomised rats
| العنوان: | Comparative study of the effects of osteoprotegerin and testosterone on bone quality in male orchidectomised rats |
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| المؤلفون: | Iván Prieto-Potin, Concepción de la Piedra, José Ramón Caeiro-Rey, David Guede, Luis Alvarez-Galovich, Francisco-Miguel Garzón-Márquez, Marta Martín-Fernández, Manuel Díaz-Curiel |
| المصدر: | The Aging Male. 23:189-201 |
| بيانات النشر: | Informa UK Limited, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Male, musculoskeletal diseases, medicine.medical_specialty, medicine.medical_treatment, 030232 urology & nephrology, 030209 endocrinology & metabolism, Bone remodeling, Random Allocation, 03 medical and health sciences, 0302 clinical medicine, Lumbar, N-terminal telopeptide, Osteoprotegerin, Bone Density, Internal medicine, medicine, Animals, Humans, Testosterone, Femur, Rats, Wistar, Saline, Bone mineral, business.industry, Spine, Rats, Endocrinology, Geriatrics and Gerontology, business, Orchiectomy, Type I collagen |
| الوصف: | Aim: The aim of this work is to compare the effects of osteoprotegerin (OPG) and testosterone on bone quality in a model of orchidectomised (ORX) rats.Methods: Three-month-old ORX or SHAM operated groups (n = 15 each group) were used. The SHAM and ORX groups received saline. There were two ORX groups, receiving OPG-Fc (10 mg/kg twice weekly) (ORX + OPG-Fc) or testosterone cypionate (1.7 mg/kg/weekly) for 8 weeks. After sacrifice, bone analysis by femoral and lumbar dual-energy X-ray absorptiometry and micro-computed tomography in femora were performed. Histological sections of vertebrae were dyed with hematoxylin-eosin or safranin. Serum osteocalcin (BGP), total alkaline phosphatase (ALP), and C-terminal telopeptide of type I collagen (CTX) were analyzed.Results: ORX resulted in femoral and vertebral bone loss and in microarchitectural deterioration. Treatment with OPG-Fc and testosterone recovered lumbar (L) and femoral (F) bone mineral densitometry bone mineral density (BMD) to SHAM levels. Femoral BMD was significantly higher after treatment with OPG-Fc than after testosterone treatment due to the presence of osteopetrotic changes in the metaphyseal region of long bones. Serum levels of ALP and CTX increased, while OPG levels were unchanged in ORX rats. Treatment with OPG-Fc decreased the levels of BGP, ALP, and CTX. Treatment with testosterone maintained biochemical markers of bone turnover at levels similar to or higher than those of ORX rats. |
| تدمد: | 1473-0790 1368-5538 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d7f75a6c27e2de38ee0dd3c8c1535d https://doi.org/10.1080/13685538.2018.1499082 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e7d7f75a6c27e2de38ee0dd3c8c1535d |
| قاعدة البيانات: | OpenAIRE |
PDF full text from Publisher | تدمد: | 14730790 13685538 |
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