Adjuvant radiotherapy in carcinomas of the uterine cervix: the prognostic value of hemoglobin levels
| العنوان: | Adjuvant radiotherapy in carcinomas of the uterine cervix: the prognostic value of hemoglobin levels |
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| المؤلفون: | P. Johnson, R. von Georgi, Karsten Münstedt, H. Vahrson, Marek Zygmunt, M. K. Bohlmann |
| المصدر: | International Journal of Gynecologic Cancer. 15:285-291 |
| بيانات النشر: | BMJ, 2005. |
| سنة النشر: | 2005 |
| مصطلحات موضوعية: | Oncology, Adult, medicine.medical_specialty, Anemia, medicine.medical_treatment, Uterine Cervical Neoplasms, Disease-Free Survival, Hemoglobins, Predictive Value of Tests, Internal medicine, medicine, Humans, Radical surgery, Aged, Neoplasm Staging, Retrospective Studies, Cervical cancer, Proportional hazards model, business.industry, Carcinoma, Obstetrics and Gynecology, Retrospective cohort study, Middle Aged, medicine.disease, Prognosis, Radiation therapy, Treatment Outcome, Predictive value of tests, Female, Radiotherapy, Adjuvant, Hemoglobin, business |
| الوصف: | Anemia has been associated with a poorer treatment response and reduced survival in women undergoing primary radiotherapy (RT) or radiochemotherapy for advanced cervical carcinoma. This study aimed to determine the influence of anemia on outcome in patients with cervical carcinoma undergoing adjuvant RT. Medical records were reviewed for 183 cervical cancer patients who had received adjuvant RT because of risk factors after radical surgery (n = 109) or inadequate primary surgery (simple hysterectomy; n = 74). Kaplan–Meier and Cox regression analyses were used to study hemoglobin levels before and during adjuvant RT in relation to recurrence-free and overall survival. Hemoglobin values ≥11 g/dL were considered normal, while those all patients = 7.5; df = 1; P = 0.006). However, subgroup analysis showed that the observed difference was mainly due to the group of women who had undergone inadequate primary surgery (overall survival—log rankinadequate surgery = 10.8; df = 1; P = 0.001). Multifactorial regression analyses comparing hemoglobin before RT with grading and tumor stage confirmed the prognostic value of hemoglobin values. Maintaining normal hemoglobin values before and during adjuvant RT seems to be important, especially in patients who have had inappropriate simple hysterectomy, which may resemble a therapeutic situation. |
| تدمد: | 1525-1438 1048-891X |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e81b519674b0a3b48ae8884ffce292b6 https://doi.org/10.1136/ijgc-00009577-200503000-00016 |
| رقم الأكسشن: | edsair.doi.dedup.....e81b519674b0a3b48ae8884ffce292b6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15251438 1048891X |
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