Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18
| العنوان: | Human papillomavirus type-distribution in cervical cancer in China: the importance of HPV 16 and 18 |
|---|---|
| المؤلفون: | Anco Molijn, David Jenkins, Yu Ling Liu, Hong Lin Zhou, Pei Yang, Qing Li, Wim Quint, Ju Fang Shi, Jing Chen, Mayinuer Niyazi, Xing Xie, Hong Shi, Lian-kun Li, Johannes E. Schmidt, Ying Hong, Mei Lu Bian, Jennifer S. Smith, You-Lin Qiao, Long Yu Li, Jihong Liu, Li Hui Wei, Qi Zhou, Xun Zhang, Jie Li, Wen Chen, Jin feng Liu, Ping Wang, L. Li |
| المصدر: | Cancer Causes & Control. 20:1705-1713 |
| بيانات النشر: | Springer Science and Business Media LLC, 2009. |
| سنة النشر: | 2009 |
| مصطلحات موضوعية: | Adult, China, Cancer Research, medicine.medical_specialty, Prevalence, Uterine Cervical Neoplasms, Cervical intraepithelial neoplasia, Polymerase Chain Reaction, Young Adult, Age Distribution, Epidemiology, medicine, Carcinoma, Humans, Young adult, Cervix, Aged, Aged, 80 and over, Cervical cancer, Gynecology, Human papillomavirus 16, Human papillomavirus 18, business.industry, Papillomavirus Infections, virus diseases, Middle Aged, Uterine Cervical Dysplasia, medicine.disease, female genital diseases and pregnancy complications, medicine.anatomical_structure, Oncology, Carcinoma, Squamous Cell, Adenocarcinoma, Female, business |
| الوصف: | Prophylactic vaccination against HPV 16 and 18 has the potential for effective prevention of high-grade precancer (cervical intraepithelial neoplasia [CIN)] 2/3) and ICC caused by these viruses (globally 50 and 70%, respectively) when employed in women prior to starting sexual activity. To provide data for decisions on HPV vaccination in China, we determined HPV type-distribution in ICC and CIN 2/3 from women of different regions within China. A multicenter study was conducted by randomized sampling of paraffin blocks of 664 ICC (630 squamous cell carcinoma [SCC]; 34 adenocarcinoma [ADC]), 569 CIN 2/3 cases from seven regions of China. Histological diagnosis was confirmed in 1,233 cases by consensus review. HPV DNA was detected using the SPF10 LiPA25 version 1 assay. HPV prevalence was 97.6% in SCC, 85.3% in adenocarcinoma, and 98.9% in CIN 2/3. HPV 16 (76.7%) and HPV 18 (7.8%) were the most common, together accounting for 84.5% of SCC, followed by HPV 31 (3.2%), HPV 52 (2.2%), and HPV 58 (2.2%). HPV positivity in SCC did not differ notably by region. However, SCC cases from womenor=34 years had higher HPV 16 positivity than women over 50 years, among whom HPV 52, 58, and 39 were more common. HPV 16 and 18 were under-represented, whereas HPV 31, 52, and 58 were over-represented in CIN2/3 compared to SCC. The potential impact of vaccines against oncogenic HPV types 16 and 18 is estimated to be high (84.5%) against total SCC. These data are critical for China's future evaluation of the cost-effectiveness of current cervical cancer vaccines and of HPV-based screening guidelines. |
| تدمد: | 1573-7225 0957-5243 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e825d3d63e3ad603e550e8e0a53f544e https://doi.org/10.1007/s10552-009-9422-z |
| حقوق: | CLOSED |
| رقم الأكسشن: | edsair.doi.dedup.....e825d3d63e3ad603e550e8e0a53f544e |
| قاعدة البيانات: | OpenAIRE |
Find this article in full text from Springer Verlag. | تدمد: | 15737225 09575243 |
|---|