Elevated C-reactive protein in early COVID-19 predicts worse survival among hospitalized geriatric patients
| العنوان: | Elevated C-reactive protein in early COVID-19 predicts worse survival among hospitalized geriatric patients |
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| المؤلفون: | Adeline Villoteau, Marine Asfar, Marie Otekpo, Jocelyne Loison, Jennifer Gautier, Cédric Annweiler, GERIA-COVID study group |
| المصدر: | PLoS ONE PLoS ONE, Vol 16, Iss 9, p e0256931 (2021) |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Viral Diseases, Cardiomyopathy, Biochemistry, Medical Conditions, Elderly, Risk Factors, Functional abilities, Medicine and Health Sciences, Longitudinal Studies, Respiratory system, Receptors, Immunologic, Virus Testing, Aged, 80 and over, Multidisciplinary, Confounding, Elevated crp, Prognosis, C-Reactive Proteins, Hospitals, Infectious Diseases, Medicine, Female, Cohort study, Research Article, medicine.medical_specialty, Coronavirus disease 2019 (COVID-19), Death Rates, Science, Elevated C-reactive protein, Population Metrics, Diagnostic Medicine, Internal medicine, Albumins, medicine, Humans, Adults, Population Biology, business.industry, COVID-19, Biology and Life Sciences, Proteins, Covid 19, medicine.disease, Health Care, Age Groups, Geriatrics, Health Care Facilities, People and Places, Population Groupings, business, Biomarkers |
| الوصف: | Background The objective of this cohort study was to determine whether elevated CRP in early COVID-19 was associated with 14-day mortality in geriatric patients. Methods Plasma CRP levels at hospital admission and 14-day all-cause mortality were assessed in geriatric inpatients hospitalized for COVID-19. Potential confounders were age, sex, functional abilities, history of malignancies, hypertension, cardiomyopathy, albuminemia, number of acute health issues, use of antibiotics and respiratory treatments. Results Ninety-five participants (mean±SD 88.0±5.5years; 49.5%women; mean CRP, 76.7±77.5mg/L; mean albuminemia, 32.9±6.0g/L) were included. Sixteen participants who did not survive at day 14 exhibited higher CRP level at baseline than the others (120.3±71.2 versus 67.9±76.1 mg/L, P = 0.002). There was no difference in albuminemia (P = 0.329). Plasma CRP level was directly associated with 14-day mortality (fully adjusted HR = 1.11, P = 0.025). The cut-off for CRP associated with 14-day mortality was set at 35mg/L (sensitivity = 0.88; specificity = 0.56). Those with CRP Conclusions Elevated CRP levels were associated with poorer 14-day survival in hospitalized geriatric COVID-19 patients. |
| تدمد: | 1932-6203 |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e84f44948d7442f77005de389f5fd6c6 https://pubmed.ncbi.nlm.nih.gov/34506514 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e84f44948d7442f77005de389f5fd6c6 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19326203 |
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