التفاصيل البيبلوغرافية
العنوان:
The discovery of an orally efficacious positive allosteric modulator of the calcium sensing receptor containing a dibenzylamine core
المؤلفون:
Yuhua Yang , Adam Davenport , Michael G. Kelly , Andrew Tasker , Michael Croghan , Guomin Yao , Fred D. Lott , Jeff D. Reagan , Christopher H. Fotsch , James Davis , Minghan Wang , Chiara Ghiron , Steve F. Poon , Qingping Zeng , David Martin , Elena Portero-Larragueta , Thomas Stephen Coulter , David J. St. Jean , Jonathan Hutchinson , Charles Henley , Kelly Regal , Paul E. Harrington , Sean Morony , Jeffrey Clarine , Jenny Ying-Lin Lu
المصدر:
Bioorganic & Medicinal Chemistry Letters . 20:5544-5547
بيانات النشر:
Elsevier BV, 2010.
سنة النشر:
2010
مصطلحات موضوعية:
Male , Agonist , Benzylamines , Allosteric modulator , Calcimimetic , medicine.drug_class , Clinical Biochemistry , Allosteric regulation , Administration, Oral , Pharmaceutical Science , Pharmacology , Biochemistry , Rats, Sprague-Dawley , Structure-Activity Relationship , chemistry.chemical_compound , In vivo , Oral administration , Drug Discovery , medicine , Animals , Molecular Biology , Chemistry , Organic Chemistry , Rats , stomatognathic diseases , Parathyroid Hormone , Molecular Medicine , Calcium-sensing receptor , Receptors, Calcium-Sensing , Lead compound
الوصف:
The discovery of a series of novel and orally efficacious type II calcimimetics, developed from the lead compound 1, is described herein. Compound 22 suppressed plasma PTH levels relative to vehicle when dosed orally in a rat pharmacodynamic model.
تدمد:
0960-894X
URL الوصول:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e863f669015b2935d346cb0793aca12e https://doi.org/10.1016/j.bmcl.2010.07.060
حقوق:
CLOSED
رقم الأكسشن:
edsair.doi.dedup.....e863f669015b2935d346cb0793aca12e
قاعدة البيانات:
OpenAIRE
