The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers
| العنوان: | The expression of the long NEAT1_2 isoform is associated with human epidermal growth factor receptor 2-positive breast cancers |
|---|---|
| المؤلفون: | Erik Knutsen, Seyed Mohammad Lellahi, Miriam Ragle Aure, Silje Nord, Silje Fismen, Kenneth Bowitz Larsen, Marta Tellez Gabriel, Annica Hedberg, Sunniva Stordal Bjørklund, Oslo Breast Cancer Research Consortium (OSBREAC), Anna Mary Bofin, Gunhild Mari Mælandsmo, Therese Sørlie, Elin Synnøve Mortensen, Maria Perander |
| المصدر: | Scientific Reports Scientific Reports, Vol 10, Iss 1, Pp 1-14 (2020) |
| بيانات النشر: | Springer Nature, 2020. |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Gene isoform, lcsh:Medicine, Locus (genetics), Breast Neoplasms, Disease, Biology, Article, Breast cancer, medicine, Humans, VDP::Medisinske Fag: 700, RNA, Neoplasm, lcsh:Science, Regulation of gene expression, Multidisciplinary, lcsh:R, RNA, Paraspeckle, medicine.disease, Paraspeckles, VDP::Medical disciplines: 700, Gene Expression Regulation, Neoplastic, Cancer research, MCF-7 Cells, Female, RNA, Long Noncoding, lcsh:Q |
| الوصف: | The long non-coding RNA NEAT1 locus is transcribed into two overlapping isoforms, NEAT1_1 and NEAT1_2, of which the latter is essential for the assembly of nuclear paraspeckles. NEAT1 is abnormally expressed in a wide variety of human cancers. Emerging evidence suggests that the two isoforms have distinct functions in gene expression regulation, and recently it was shown that NEAT1_2, but not NEAT1_1, expression predicts poor clinical outcome in cancer. Here, we report that NEAT1_2 expression correlates with HER2-positive breast cancers and high-grade disease. We provide evidence that NEAT1_1 and NEAT1_2 have distinct expression pattern among different intrinsic breast cancer subtypes. Finally, we show that NEAT1_2 expression and paraspeckle formation increase upon lactation in humans, confirming what has previously been demonstrated in mice. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
| وصف الملف: | application/pdf |
| اللغة: | English |
| URL الوصول: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8642f8452283cdfe9a9cc608e51fef1 https://hdl.handle.net/11250/2657634 |
| حقوق: | OPEN |
| رقم الأكسشن: | edsair.doi.dedup.....e8642f8452283cdfe9a9cc608e51fef1 |
| قاعدة البيانات: | OpenAIRE |
| الوصف غير متاح. |